Avanafil
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Phosphodiesterase 5 Inhibitor
Controlled Drug Substance
NO
Avanafil
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Click HereSummary
Avanafil is used to treat erectile dysfunction in adult men. It helps them achieve and maintain an erection sufficient for satisfactory sexual performance.
Avanafil works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). This leads to increased levels of a substance called cyclic guanosine monophosphate (cGMP) in the body, which relaxes the muscles in the penis and increases blood flow. This helps facilitate an erection during sexual stimulation.
The usual starting dose of Avanafil is 100 mg, taken as needed about 15 minutes before sexual activity. Depending on effectiveness and tolerance, the dose may be increased to 200 mg or decreased to 50 mg. It is not intended for continuous daily use and the maximum recommended frequency is once per day.
Common side effects of Avanafil include headache, flushing, and nasal congestion. Serious adverse effects can include prolonged erection, sudden vision or hearing loss, and severe low blood pressure which require immediate medical attention.
Avanafil should not be used with nitrates or guanylate cyclase stimulators as it can cause severe low blood pressure. It is also contraindicated in patients with severe cardiovascular conditions, recent heart attack or stroke, and those with severe liver or kidney impairment. Drinking alcohol while taking Avanafil can increase the likelihood of experiencing certain side effects.
Indications and Purpose
What is Avanafil used for?
Avanafil is indicated for the treatment of erectile dysfunction in adult males. It helps men achieve and maintain an erection sufficient for sexual activity.
How does Avanafil work?
Avanafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which increases levels of cyclic guanosine monophosphate (cGMP) in the penis. This leads to smooth muscle relaxation and increased blood flow, facilitating an erection during sexual stimulation.
Is Avanafil effective?
Clinical trials have shown that Avanafil is effective in treating erectile dysfunction. It improves the ability to achieve and maintain an erection sufficient for sexual activity. Studies have demonstrated statistically significant improvements in erectile function compared to placebo.
How does one know if Avanafil is working?
The benefit of Avanafil is evaluated through its ability to improve erectile function, as measured by the International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) questions. Patients should discuss their response to treatment with their doctor.
Directions for Use
What is the usual dose of Avanafil?
Avanafil is prescribed for adult males with erectile dysfunction. The usual starting dose is 100 mg, taken as needed about 15 minutes before sexual activity. Depending on effectiveness and tolerance, the dose can be increased to 200 mg or decreased to 50 mg. Avanafil is not recommended for use in children.
How do I take Avanafil?
Avanafil can be taken with or without food. For the 100 mg or 200 mg doses, take it about 15 minutes before sexual activity. For the 50 mg dose, take it about 30 minutes before. Avoid grapefruit juice, as it may increase Avanafil levels in the body.
For how long do I take Avanafil?
Avanafil is used as needed for erectile dysfunction, typically taken 15 to 30 minutes before sexual activity. It is not intended for continuous daily use, and the maximum recommended frequency is once per day.
How long does it take for Avanafil to start working?
Avanafil typically starts working within 15 to 30 minutes after taking the medication, depending on the dose. Sexual stimulation is required for the medication to be effective.
How should I store Avanafil?
Store Avanafil in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
Warnings and Precautions
Who should avoid taking Avanafil?
Avanafil should not be used with nitrates or guanylate cyclase stimulators due to the risk of severe hypotension. It is contraindicated in patients with severe cardiovascular conditions, recent heart attack or stroke, and severe liver or kidney impairment. Consult your doctor for a full list of contraindications.
Can I take Avanafil with other prescription drugs?
Avanafil should not be used with nitrates or guanylate cyclase stimulators due to the risk of severe hypotension. It should be used cautiously with alpha-blockers and antihypertensives. Strong CYP3A4 inhibitors can increase Avanafil levels, requiring dose adjustments.
Can I take Avanafil with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Avanafil be taken safely while pregnant?
Avanafil is not indicated for use in women, including during pregnancy. There is no data on its use in pregnant women, and it is not recommended for use in this population.
Can Avanafil be taken safely while breastfeeding?
Avanafil is not indicated for use in women, including those who are breastfeeding. There is no information on its presence in human or animal milk, and it is not recommended for use in this population.
Is Avanafil safe for the elderly?
Elderly patients (65 years and older) can use Avanafil without dose adjustment based on age alone. However, they may have increased sensitivity to the medication. It's important for elderly patients to consult their doctor to ensure the medication is safe and effective for them.
Is it safe to exercise while taking Avanafil?
Avanafil does not specifically limit the ability to exercise. However, since it can cause dizziness or low blood pressure, it's important to be cautious when engaging in physical activities. If you experience any adverse effects during exercise, consult your doctor.
Is it safe to drink alcohol while taking Avanafil?
Drinking alcohol while taking Avanafil can increase the likelihood of experiencing side effects such as dizziness, headache, and low blood pressure. It is advised to limit alcohol consumption to avoid these potential interactions and ensure the medication's effectiveness.
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