Auranofin
Psoriatic Arthritis, Rheumatoid Arthritis ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
NA
Controlled Drug Substance
NO
Auranofin
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Auranofin is primarily used to manage rheumatoid arthritis in adults who have not responded adequately to nonsteroidal anti-inflammatory drugs. It can also be used for psoriatic arthritis, but this should be discussed with your doctor.
Auranofin works by modifying the activity of rheumatoid arthritis, although its exact mechanism is not fully understood. It contains gold, which is thought to reduce inflammation and slow down the progression of the disease.
The usual adult dosage of Auranofin is 6 mg daily, taken orally. It can be taken as 3 mg twice daily or 6 mg once daily. If the response is inadequate after six months, the dose may be increased to 9 mg daily.
Common side effects of Auranofin include diarrhea, abdominal pain, and nausea with or without vomiting. It may also cause rash, pruritus (itching), and fatigue.
Auranofin should not be used by patients with a history of gold-induced disorders. It is also not recommended for use during pregnancy or breastfeeding. It should be used with caution in combination with other medications due to potential interactions.
Indications and Purpose
What is Auranofin used for?
Auranofin is indicated for the management of adults with active classical or definite rheumatoid arthritis who have not responded adequately to nonsteroidal anti-inflammatory drugs. It is also sometimes used for psoriatic arthritis, but patients should discuss the risks and benefits with their doctor.
How does Auranofin work?
Auranofin works by modifying the activity of rheumatoid arthritis, although its exact mechanism of action is not fully understood. It contains gold, which is thought to reduce inflammation and slow down the progression of the disease, helping to alleviate symptoms like joint pain and swelling.
Is Auranofin effective?
Auranofin is used to treat rheumatoid arthritis and may modify disease activity as shown by reduced synovitis and associated symptoms. However, there is no substantial evidence that gold-containing compounds like Auranofin induce remission of rheumatoid arthritis. Clinical studies have shown that therapeutic effects may be seen after three to four months of treatment.
How does one know if Auranofin is working?
The benefit of Auranofin is evaluated through regular doctor appointments and laboratory tests. These tests check the patient's response to the medication, including monitoring blood-gold concentrations and assessing any side effects. Patients should keep all appointments with their doctor to ensure the medication is working effectively.
Directions for Use
What is the usual dose of Auranofin?
The usual adult dosage of Auranofin is 6 mg daily, which can be taken as 3 mg twice daily or 6 mg once daily. If the response is inadequate after six months, the dose may be increased to 9 mg daily. Auranofin is not recommended for use in children as its safety and effectiveness have not been established for pediatric patients.
How do I take Auranofin?
Auranofin should be taken exactly as prescribed by your doctor, usually once or twice a day. It is recommended to take it after meals or a light snack to minimize stomach upset. There are no specific food restrictions, but alcohol should be avoided while taking this medication.
For how long do I take Auranofin?
Auranofin is typically used for long-term management of rheumatoid arthritis. The full effect of the medication is usually felt after 3-4 months, but it may take up to 6 months for some individuals. The duration of use depends on the patient's response and the doctor's recommendation.
How long does it take for Auranofin to start working?
Auranofin typically takes 3-4 months to start showing its full effect, although some people may take up to 6 months to experience the benefits. It is important to take the medication regularly as prescribed to achieve the desired therapeutic effect.
How should I store Auranofin?
Auranofin should be stored in the container it came in, tightly closed, and out of reach of children. It should be kept at room temperature, away from excess heat and moisture, and not stored in the bathroom. Proper storage helps maintain the medication's effectiveness and safety.
Warnings and Precautions
Who should avoid taking Auranofin?
Auranofin is contraindicated in patients with a history of gold-induced disorders such as anaphylactic reactions, necrotizing enterocolitis, and severe hematologic disorders. Warnings include the risk of gold toxicity, which can cause symptoms like a fall in hemoglobin, leukopenia, and thrombocytopenia. Patients should be monitored for these signs, and the medication should be discontinued if they occur.
Can I take Auranofin with other prescription drugs?
Auranofin's safety with other medications like injectable gold, hydroxychloroquine, penicillamine, immunosuppressive agents, or high doses of corticosteroids has not been established. There is a suggestion that concurrent administration with phenytoin may increase phenytoin blood levels. Always inform your doctor about all medications you are taking to avoid potential interactions.
Can I take Auranofin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Auranofin be taken safely while pregnant?
Auranofin is not recommended for use during pregnancy. Women of childbearing potential should be warned of the potential risks, as animal studies have shown adverse effects on fetal development. There are no adequate and well-controlled studies in pregnant women, so it is best to avoid using Auranofin during pregnancy.
Can Auranofin be taken safely while breastfeeding?
Nursing during Auranofin therapy is not recommended. Gold has been found in the milk of nursing animals and women after administration of gold compounds. Since human data on Auranofin are not available, it is advised to avoid breastfeeding while taking this medication.
Is Auranofin safe for the elderly?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to exercise while taking Auranofin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Auranofin?
It is advised not to drink alcohol while taking Auranofin. Alcohol can increase the risk of side effects and may affect the safety and effectiveness of the medication. Always consult your doctor for personalized advice regarding alcohol consumption while on Auranofin.