Atorvastatin
Coronary Artery Disease, Hypercholesterolemia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
HMG-CoA Reductase Inhibitor
Controlled Drug Substance
NO
Atorvastatin
Learn more about this medicine -
Click HereSummary
Atorvastatin is used to lower high cholesterol levels, raise good cholesterol, lower triglyceride levels, and reduce the risk of heart attacks, strokes, and other heart-related issues.
Atorvastatin works by blocking an enzyme in the liver that is responsible for making cholesterol. By reducing cholesterol production, it helps lower total cholesterol levels in the blood.
Atorvastatin is typically taken once a day, either before or after you eat. If taken before eating, wait at least 1 hour after taking it. If taken after eating, wait at least 2 hours after taking it.
Common side effects of Atorvastatin include stuffy nose, sore throat, diarrhea, urinary tract infection, upset stomach, nausea, muscle cramps, joint pain, trouble sleeping, and in serious cases, muscle damage and liver problems.
Atorvastatin is not recommended for pregnant or breastfeeding women. It can interact with several medications, so always inform your doctor about all the medications you're taking to avoid dangerous interactions. If you experience significant mood changes, muscle pain, or discomfort, contact your doctor immediately.
Indications and Purpose
What is Atorvastatin used for?
Atorvastatin is indicated for the treatment of high cholesterol, including familial hypercholesterolemia, and for reducing the risk of heart attack, stroke, and other cardiovascular events in individuals with or at risk for heart disease. It is also used to manage lipid levels in patients with type 2 diabetes and other risk factors for cardiovascular disease.
How does Atorvastatin work?
Atorvastatin works by inhibiting the enzyme HMG-CoA reductase in the liver, which is responsible for producing cholesterol. This leads to a decrease in cholesterol production, reducing the amount of cholesterol that can accumulate in the arteries and improving overall cardiovascular health.
Is Atorvastatin effective?
Atorvastatin is effective in lowering LDL cholesterol and reducing the risk of cardiovascular events. Clinical trials have shown significant reductions in LDL-C, total cholesterol, and triglycerides, as well as a decrease in the risk of heart attacks and strokes in patients with high cholesterol or cardiovascular risk factors.
How does one know if Atorvastatin is working?
The benefit of Atorvastatin is evaluated through regular blood tests to monitor cholesterol levels. Your doctor will assess your LDL-C, total cholesterol, and triglyceride levels to determine the effectiveness of the treatment and make any necessary dosage adjustments.
Directions for Use
What is the usual dose of Atorvastatin?
For adults, the usual starting dose of Atorvastatin is 10 mg to 20 mg once daily, with a range of 10 mg to 80 mg per day. For children aged 10 years and older with heterozygous familial hypercholesterolemia, the starting dose is typically 10 mg once daily, with a range of 10 mg to 20 mg per day. Always follow your doctor's specific dosage instructions.
How do I take Atorvastatin?
Atorvastatin can be taken with or without food, but it should be taken at the same time each day. Avoid consuming large amounts of grapefruit juice, as it can increase the risk of side effects. Follow your doctor's dietary recommendations to enhance the effectiveness of the medication.
For how long do I take Atorvastatin?
Atorvastatin is typically used as a long-term treatment to manage cholesterol levels and reduce the risk of heart disease. The duration of use depends on individual health needs and response to the medication. Your doctor will guide you on how long you should continue taking Atorvastatin.
How long does it take for Atorvastatin to start working?
Atorvastatin begins to work within about two weeks, but it may take up to four weeks to see the full effect on cholesterol levels. Regular monitoring by your doctor will help assess the medication's effectiveness.
How should I store Atorvastatin?
Atorvastatin should be stored at room temperature, away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, and dispose of any unused medication properly.
Warnings and Precautions
Who should avoid taking Atorvastatin?
Important warnings for Atorvastatin include the risk of muscle problems, liver damage, and potential interactions with other medications. It is contraindicated in patients with active liver disease, during pregnancy, and while breastfeeding. Patients should inform their doctor of any other medications they are taking to avoid interactions.
Can I take Atorvastatin with other prescription drugs?
Significant drug interactions with Atorvastatin include those with cyclosporine, certain antiviral medications, and some antibiotics like clarithromycin. These can increase the risk of muscle problems. Always inform your doctor of all medications you are taking to avoid harmful interactions.
Can I take Atorvastatin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Atorvastatin be taken safely while pregnant?
Atorvastatin is contraindicated during pregnancy due to the risk of fetal harm. It can affect cholesterol synthesis, which is crucial for fetal development. Women who are pregnant or planning to become pregnant should not use Atorvastatin and should discuss alternative treatments with their doctor.
Can Atorvastatin be taken safely while breastfeeding?
Atorvastatin is not recommended during breastfeeding as it may pass into breast milk and harm the infant. Women who are breastfeeding should discuss alternative treatments with their doctor to manage cholesterol levels safely.
Is Atorvastatin safe for the elderly?
Elderly patients may have an increased risk of myopathy when taking Atorvastatin. It's important for older adults to be monitored closely for muscle-related symptoms. Dosage adjustments may be necessary based on individual health conditions and response to the medication.
Is it safe to exercise while taking Atorvastatin?
Atorvastatin does not typically limit the ability to exercise. However, if you experience muscle pain or weakness, which can be a side effect, it may affect your ability to exercise. Consult your doctor if you notice any muscle-related symptoms.
Is it safe to drink alcohol while taking Atorvastatin?
Drinking alcohol can increase the risk of liver damage when taking Atorvastatin. It's important to discuss your alcohol consumption with your doctor, as they may advise you to limit or avoid alcohol to reduce the risk of serious side effects.
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