Atazanavir
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Protease Inhibitor
Controlled Drug Substance
NO
Atazanavir
Learn more about this medicine -
Click HereSummary
Atazanavir is used to treat and manage HIV-1 infections. It helps reduce the virus levels in the blood, improving immune health, preventing complications, and delaying the disease's progression.
Atazanavir works by blocking HIV protease, an enzyme that the virus needs to multiply and mature. This slows HIV replication, reducing the virus's presence and improving the immune response over time.
The typical adult dose is 300 mg of Atazanavir taken once daily with ritonavir 100 mg. For children, the dose is weight-based and determined by the doctor. The medication is taken orally.
Atazanavir may cause nausea, jaundice, diarrhea, or abdominal pain. Some patients might experience difficulty concentrating or mild mental fog. Fatigue is a possible but uncommon side effect. Serious risks include liver issues, kidney stones, and changes in heart rhythm.
People with severe liver impairment, known allergic reactions to Atazanavir, or taking specific medications like rifampin or St. John's Wort should avoid it. Breastfeeding is not recommended for HIV-positive mothers on Atazanavir. The medication interacts with many other drugs, so always share your full medication list with your doctor.
Indications and Purpose
What is Atazanavir used for?
Atazanavir is used to treat and manage HIV-1 infections. By reducing the virus levels in the blood and improving immune health, it helps prevent complications and delays the progression of the disease.
How does Atazanavir work?
Atazanavir blocks HIV protease, an enzyme the virus needs to multiply and mature. This action slows HIV replication, reducing the virus's presence and improving immune response over time.
Is Atazanavir effective?
Yes, Atazanavir is highly effective in managing HIV when used as part of combination antiretroviral therapy. Studies show significant reductions in viral load and improvements in CD4 cell counts with proper usage.
How does one know if Atazanavir is working?
Regular monitoring through blood tests helps assess Atazanavir's effectiveness. A decreasing viral load and stable or rising CD4 counts are indicators that the medication is working.
Directions for Use
What is the usual dose of Atazanavir?
The typical adult dose is 300 mg of Atazanavir taken once daily with ritonavir (100 mg). For children, the dose is weight-based and determined by the doctor. Always follow medical advice for precise dosing.
How do I take Atazanavir?
Take Atazanavir with food to improve absorption. Swallow capsules whole with water, avoiding antacids or supplements with calcium, magnesium, or aluminum within 2 hours of your dose. Always stick to your doctor’s instructions.
For how long do I take Atazanavir?
Atazanavir is usually taken for life to manage HIV infection effectively. Stopping treatment may lead to increased viral load and decreased immune function. Consult your doctor for any changes to the treatment plan.
How long does it take for Atazanavir to start working?
Atazanavir begins working within a few days to suppress HIV replication. Significant improvements in viral load and immune markers may take weeks to months, depending on adherence to the treatment plan.
How should I store Atazanavir?
Store Atazanavir at room temperature (15–30°C) in a dry place. Keep it away from moisture, direct sunlight, and out of reach of children. Do not use the medication after its expiration date.
Warnings and Precautions
Who should avoid taking Atazanavir?
People with severe liver impairment, known allergic reactions to Atazanavir, or taking specific medications like rifampin or St. John’s Wort should avoid it. Always inform your doctor of your medical history.
Can I take Atazanavir with other prescription drugs?
Atazanavir interacts with many medications, including those for seizures, heartburn, and cholesterol. Such interactions can lower its effectiveness or increase side effects. Always share your full medication list with your doctor.
Can I take Atazanavir with vitamins or supplements?
Avoid taking antacids, multivitamins, or supplements containing aluminum, magnesium, or calcium within 2 hours of Atazanavir, as they interfere with absorption. Discuss all supplements with your doctor before use.
Can Atazanavir be taken safely while pregnant?
Yes, Atazanavir is often considered safe during pregnancy to prevent HIV transmission to the baby. Consult your doctor to ensure the correct dosing and to monitor your health during treatment.
Can Atazanavir be taken safely while breastfeeding?
Breastfeeding is not recommended for HIV-positive mothers, even when on Atazanavir, to eliminate the risk of transmitting HIV through breast milk. Discuss feeding options with your healthcare provider.
Is Atazanavir safe for the elderly?
Elderly patients can use Atazanavir, but they should be monitored closely for liver and kidney function, as these may decline with age. Report any unusual side effects promptly to the doctor.
Is it safe to exercise while taking Atazanavir?
Exercise is safe and beneficial while taking Atazanavir. However, if you feel fatigued or unwell, adjust your routine and discuss concerns with your doctor for proper guidance.
Is it safe to drink alcohol while taking Atazanavir?
Limit alcohol consumption as it can increase the risk of liver issues with Atazanavir. Occasional drinking may be safe, but it’s best to consult your doctor for personalized advice.
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