Aspirin + Meprobamate

Find more information about this combination medication at the webpages for Aspirin and Meprobamate

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Approved Treatment Indication:

Rheumatoid Arthritis, Headache ... show more

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Advisory

This medicine contains a combination of 2 drugs Aspirin and Meprobamate.
Each of these drugs treats a different disease or symptom.
Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Aspirin and Meprobamate used for?
Aspirin is used to relieve pain, reduce inflammation, and lower the risk of heart attacks and strokes by preventing blood clots. It is also used for conditions like arthritis and systemic lupus erythematosus, which is an autoimmune disease causing inflammation in various parts of the body. Meprobamate is used to treat anxiety disorders, providing short-term relief of anxiety symptoms. While both medications can be used for different conditions, they share a common role in managing symptoms related to the central nervous system, albeit through different mechanisms.
How do Aspirin and Meprobamate work in the body?
Aspirin works by inhibiting the production of prostaglandins, which are substances in the body that cause inflammation, pain, and fever. It also prevents blood clots by inhibiting platelet aggregation, which is the clumping together of blood cells. Meprobamate acts as a tranquilizer by slowing down brain activity, which helps to relieve anxiety. Both medications affect the central nervous system but do so in different ways: aspirin primarily targets pain and inflammation, while meprobamate focuses on reducing anxiety.
What are the usual dosages and routes of administration for Aspirin and Meprobamate?
For aspirin, the usual adult daily dose varies depending on the condition being treated. For pain relief, it is typically 325 mg to 650 mg every 4 to 6 hours, not exceeding 4,000 mg per day. For heart attack or stroke prevention, a lower dose of 81 mg to 325 mg once daily is common. Meprobamate is usually prescribed at 1,200 mg to 1,600 mg per day, divided into three or four doses. Both medications are taken orally, which means by mouth, and should be taken as directed by a healthcare provider.
What are the most commonly observed adverse effects of Aspirin and Meprobamate?
Common side effects of aspirin include nausea, vomiting, stomach pain, and heartburn. Serious adverse effects can include allergic reactions, bleeding, and gastrointestinal ulcers, which are sores in the stomach lining. Meprobamate may cause drowsiness, dizziness, nausea, and in severe cases, allergic reactions, difficulty breathing, and irregular heartbeat. Both medications can cause serious side effects, particularly when taken in high doses or for extended periods, and require monitoring by a healthcare provider.
What are the important safety warnings and contraindications for Aspirin and Meprobamate?
Aspirin should not be used by individuals with a history of bleeding disorders, stomach ulcers, or aspirin allergies. Meprobamate is contraindicated in individuals with a history of drug abuse or severe liver or kidney disease. Both medications should be used with caution in the elderly and those with chronic health conditions. Aspirin is generally not recommended during breastfeeding due to the risk of Reye's syndrome, which is a rare but serious condition in infants. Meprobamate is present in breast milk and its use is not recommended during breastfeeding due to potential effects on the infant.

Government Approvals

None

WHO Essential Medicine

NO

Known Teratogen

NO

Pharmaceutical Class

Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation Inhibitor

Controlled Drug Substance

NO

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Drug Ingredient

Aspirin + Meprobamate

Summary

What conditions are Aspirin and Meprobamate used for?
Aspirin is used to relieve pain, reduce inflammation, and lower the risk of heart attacks and strokes by preventing blood clots. It is also used for conditions like arthritis and systemic lupus erythematosus, which is an autoimmune disease causing inflammation in various parts of the body. Meprobamate is used to treat anxiety disorders, providing short-term relief of anxiety symptoms. While both medications can be used for different conditions, they share a common role in managing symptoms related to the central nervous system, albeit through different mechanisms.
How do Aspirin and Meprobamate work in the body?
Aspirin works by inhibiting the production of prostaglandins, which are substances in the body that cause inflammation, pain, and fever. It also prevents blood clots by inhibiting platelet aggregation, which is the clumping together of blood cells. Meprobamate acts as a tranquilizer by slowing down brain activity, which helps to relieve anxiety. Both medications affect the central nervous system but do so in different ways: aspirin primarily targets pain and inflammation, while meprobamate focuses on reducing anxiety.
What are the usual dosages and routes of administration for Aspirin and Meprobamate?
For aspirin, the usual adult daily dose varies depending on the condition being treated. For pain relief, it is typically 325 mg to 650 mg every 4 to 6 hours, not exceeding 4,000 mg per day. For heart attack or stroke prevention, a lower dose of 81 mg to 325 mg once daily is common. Meprobamate is usually prescribed at 1,200 mg to 1,600 mg per day, divided into three or four doses. Both medications are taken orally, which means by mouth, and should be taken as directed by a healthcare provider.
What are the most commonly observed adverse effects of Aspirin and Meprobamate?
Common side effects of aspirin include nausea, vomiting, stomach pain, and heartburn. Serious adverse effects can include allergic reactions, bleeding, and gastrointestinal ulcers, which are sores in the stomach lining. Meprobamate may cause drowsiness, dizziness, nausea, and in severe cases, allergic reactions, difficulty breathing, and irregular heartbeat. Both medications can cause serious side effects, particularly when taken in high doses or for extended periods, and require monitoring by a healthcare provider.
What are the important safety warnings and contraindications for Aspirin and Meprobamate?
Aspirin should not be used by individuals with a history of bleeding disorders, stomach ulcers, or aspirin allergies. Meprobamate is contraindicated in individuals with a history of drug abuse or severe liver or kidney disease. Both medications should be used with caution in the elderly and those with chronic health conditions. Aspirin is generally not recommended during breastfeeding due to the risk of Reye's syndrome, which is a rare but serious condition in infants. Meprobamate is present in breast milk and its use is not recommended during breastfeeding due to potential effects on the infant.

Indications and Purpose

How does combination of Aspirin and Meprobamate work?

Aspirin works by inhibiting the production of prostaglandins, substances in the body that cause inflammation, pain, and fever, and it also prevents blood clots by inhibiting platelet aggregation. Meprobamate acts as a tranquilizer by slowing down brain activity, which helps to relieve anxiety. Both medications affect the central nervous system but do so in different ways: aspirin primarily targets pain and inflammation, while meprobamate focuses on reducing anxiety.

How effective is combination of Aspirin and Meprobamate?

Aspirin's effectiveness is well-documented in reducing pain, inflammation, and preventing cardiovascular events, supported by numerous clinical studies. Meprobamate's effectiveness in treating anxiety is also supported by clinical use, although it is less commonly prescribed today due to the availability of safer alternatives. Both medications have been used for decades, providing substantial evidence of their efficacy in their respective areas. However, both require careful monitoring to manage potential side effects and interactions.

Directions for Use

What is the usual dose of combination of Aspirin and Meprobamate?

For aspirin, the usual adult daily dose varies depending on the condition being treated. For pain relief, it is typically 325 mg to 650 mg every 4 to 6 hours, not exceeding 4,000 mg per day. For heart attack or stroke prevention, a lower dose of 81 mg to 325 mg once daily is common. Meprobamate is usually prescribed at 1,200 mg to 1,600 mg per day, divided into three or four doses. Both medications should be taken as directed by a healthcare provider, and the doses may be adjusted based on individual needs and responses.

How does one take combination of Aspirin and Meprobamate?

Aspirin should be taken with a full glass of water and can be taken with food to minimize stomach upset. Meprobamate should also be taken with water, and while there are no specific food restrictions, it is important to avoid alcohol as it can enhance the sedative effects. Both medications should be taken exactly as prescribed, and patients should consult their healthcare provider for any specific dietary instructions or restrictions.

For how long is combination of Aspirin and Meprobamate taken?

Aspirin can be used both short-term for pain relief and long-term for cardiovascular protection, depending on the condition being treated. Meprobamate is generally prescribed for short-term use due to the risk of dependence and should not be used for more than a few weeks without medical supervision. Both medications require careful monitoring by a healthcare provider to ensure safe and effective use, especially when used for extended periods.

How long does it take for combination of Aspirin and Meprobamate to work?

Aspirin and Meprobamate have different onset times due to their distinct mechanisms of action. Aspirin, when taken in its regular form, begins to work within 30 minutes to an hour, providing relief from pain and inflammation. Meprobamate, on the other hand, is used for anxiety relief and may take a bit longer to show effects, typically within an hour. Both medications are absorbed through the gastrointestinal tract, but their effects are felt at different times due to their unique purposes: aspirin for pain and inflammation, and meprobamate for anxiety.

Warnings and Precautions

Are there harms and risks from taking combination of Aspirin and Meprobamate?

Common side effects of aspirin include nausea, vomiting, stomach pain, and heartburn. Serious adverse effects can include allergic reactions, bleeding, and gastrointestinal ulcers. Meprobamate may cause drowsiness, dizziness, nausea, and in severe cases, allergic reactions, difficulty breathing, and irregular heartbeat. Both medications can cause serious side effects, particularly when taken in high doses or for extended periods, and require monitoring by a healthcare provider.

Can I take combination of Aspirin and Meprobamate with other prescription drugs?

Aspirin can interact with anticoagulants like warfarin, increasing the risk of bleeding, and with other NSAIDs, which can enhance side effects. Meprobamate can interact with other CNS depressants, such as benzodiazepines, increasing sedation and risk of overdose. Both medications require careful monitoring when used with other drugs, and patients should inform their healthcare provider of all medications they are taking to avoid harmful interactions.

Can I take combination of Aspirin and Meprobamate if I am pregnant?

Aspirin is generally avoided during pregnancy, especially in the third trimester, due to risks of bleeding and complications during delivery. Meprobamate is also not recommended during pregnancy as it may harm the fetus. Both medications should only be used if the potential benefits justify the risks, and under strict medical supervision. Pregnant women should consult their healthcare provider before using these medications to ensure safety for both mother and child.

Can I take combination of Aspirin and Meprobamate while breastfeeding?

Aspirin is generally not recommended during breastfeeding due to the risk of Reye's syndrome in infants. Meprobamate is present in breast milk at higher concentrations than in maternal plasma, and its use is not recommended during breastfeeding due to potential effects on the infant. Both medications should be used with caution, and alternative treatments should be considered for breastfeeding mothers. Consultation with a healthcare provider is essential to weigh the risks and benefits.

Who should avoid taking combination of Aspirin and Meprobamate?

Aspirin should not be used by individuals with a history of bleeding disorders, stomach ulcers, or aspirin allergies. Meprobamate is contraindicated in individuals with a history of drug abuse or severe liver or kidney disease. Both medications should be used with caution in the elderly and those with chronic health conditions. Patients should be aware of the potential for serious side effects and interactions, and use these medications only under the guidance of a healthcare provider.