Asciminib
Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Asciminib
Summary
Asciminib is used to treat chronic myeloid leukemia (CML) in adults, particularly those with the Philadelphia chromosome-positive type. This type of cancer affects the white blood cells and tends to progress slowly over many years.
Asciminib works by blocking a specific protein that promotes the growth of cancer cells. This protein is known as ABL-BCR-ABL1 tyrosine kinase and is responsible for the spread of cancer cells in chronic myeloid leukemia. By inhibiting this protein, Asciminib helps to stop the growth and spread of these cells.
The usual daily dose for adults with newly diagnosed or previously treated chronic myeloid leukemia is 80 mg once daily or 40 mg twice daily. For those with a specific mutation called T315I, the recommended dose is 200 mg twice daily. Asciminib is taken orally, and patients should avoid eating for at least 2 hours before and 1 hour after taking the medication.
Common side effects of Asciminib include musculoskeletal pain, rash, fatigue, diarrhea, and headache. Serious side effects can include myelosuppression (a decrease in the production of blood cells), pancreatic toxicity, hypertension (high blood pressure), hypersensitivity, and cardiovascular toxicity.
Asciminib can cause harm to a fetus, so it should not be used during pregnancy. Women who are breastfeeding should also avoid this medication due to the potential for serious adverse reactions in the breastfed child. Asciminib can interact with certain medications, so patients should inform their doctor of all medications they are taking to avoid harmful interactions.
Indications and Purpose
How does Asciminib work?
Asciminib works by inhibiting a specific protein called BCR-ABL1, which is involved in the growth of cancer cells in chronic myeloid leukemia. Think of it like turning off a switch that allows cancer cells to grow and multiply. By blocking this protein, Asciminib helps slow down or stop the progression of the disease, improving health outcomes for patients.
Is Asciminib effective?
Asciminib is effective in treating certain types of chronic myeloid leukemia, which is a cancer of the blood and bone marrow. It works by targeting specific proteins in cancer cells, helping to stop their growth. Clinical studies have shown that Asciminib can significantly improve health outcomes in patients with this condition. Always follow your doctor's advice and attend regular check-ups to monitor your progress.
What is Asciminib?
Asciminib is a medication used to treat chronic myeloid leukemia, which is a cancer of the blood and bone marrow. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking specific proteins that promote cancer cell growth. Asciminib is used when other treatments have not been effective or are not suitable. It helps control the disease and improve patient outcomes.
Directions for Use
For how long do I take Asciminib?
Asciminib is usually a long-term medication for managing chronic myeloid leukemia, which is a cancer of the blood and bone marrow. You'll typically take Asciminib every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Asciminib treatment.
How do I dispose of Asciminib?
If you can, bring unused Asciminib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Asciminib?
Asciminib is usually taken twice daily, once in the morning and once in the evening. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Never take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Asciminib to start working?
Asciminib begins working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and how your body responds to the medication. Regular check-ups with your doctor are important to monitor your progress and adjust your treatment as needed.
How should I store Asciminib?
Store Asciminib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep Asciminib out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Asciminib?
The usual starting dose of Asciminib for adults is 40 mg taken twice daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. It's important to follow your doctor's specific dosing instructions for your personal health needs. Always consult your healthcare provider before making any changes to your medication regimen.
Warnings and Precautions
Can Asciminib be taken safely while breastfeeding?
Asciminib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. While we don't have specific reports of harm to breastfed babies from Asciminib, we can't rule out potential risks. If you're taking Asciminib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Asciminib be taken safely while pregnant?
Asciminib isn't recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but we lack sufficient human data. Uncontrolled cancer during pregnancy can cause serious problems for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan.
Can I take Asciminib with other prescription drugs?
Asciminib can interact with certain medications, including those that affect liver enzymes. These interactions can increase the risk of side effects or reduce the effectiveness of Asciminib. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
Does Asciminib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Asciminib include nausea, fatigue, and high blood pressure. These effects vary in frequency and severity. Serious side effects can include liver problems and high blood pressure. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Asciminib and recommend appropriate actions.
Does Asciminib have any safety warnings?
Asciminib has important safety warnings. It can cause high blood pressure and liver problems. Regular monitoring of blood pressure and liver function is recommended. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, contact your doctor immediately. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms.
Is Asciminib addictive?
Asciminib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Asciminib works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Asciminib doesn't carry this risk.
Is Asciminib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Asciminib, such as high blood pressure and liver problems. Regular monitoring is important to ensure safety. Asciminib can be used in elderly patients, but they may require closer observation and dose adjustments. Always consult your doctor about any concerns and inform them of your medical history before starting Asciminib.
Is it safe to drink alcohol while taking Asciminib?
It's best to avoid alcohol while taking Asciminib. Alcohol can affect liver function, and Asciminib can also impact the liver. Drinking alcohol may increase the risk of liver problems. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or fatigue. Talk with your doctor about alcohol use while taking Asciminib for personalized advice.
Is it safe to exercise while taking Asciminib?
You can exercise while taking Asciminib, but keep a few things in mind. Asciminib can cause fatigue, which might affect your exercise capacity. If you feel unusually tired or weak during workouts, slow down or stop exercising and rest. To exercise safely, listen to your body and avoid overexertion. Most people can maintain their regular exercise routine while taking Asciminib, but check with your doctor if you have concerns.
Is it safe to stop Asciminib?
Stopping Asciminib suddenly can cause your condition to worsen. It's usually used for long-term treatment of chronic conditions like cancer. If you stop taking it without medical advice, your cancer may progress. Always talk with your doctor before stopping Asciminib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Asciminib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Asciminib include nausea, fatigue, and high blood pressure. These effects vary from person to person. If you notice new symptoms after starting Asciminib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication to ensure your treatment remains effective.
Who should avoid taking Asciminib?
Don't take Asciminib if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Asciminib should be used with caution in patients with liver problems, as it can affect liver function. Always consult your doctor about any concerns and inform them of your medical history before starting Asciminib.
