Alpelisib
Breast Neoplasms, Male, Breast Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Alpelisib
Summary
Alpelisib is used to treat certain types of breast cancer, specifically hormone receptor-positive, HER2-negative breast cancer with a PIK3CA mutation, which is a change in a gene that can lead to cancer growth.
Alpelisib works by blocking a protein called PI3K, which helps cancer cells grow and survive. This action slows down the growth of cancer cells and can shrink tumors, helping to manage the disease.
The usual starting dose of Alpelisib for adults is 300 mg taken once daily with food. It is important to follow your doctor's specific dosing instructions and not change your dose without consulting your healthcare provider.
Common side effects of Alpelisib include high blood sugar, diarrhea, and rash. These effects can vary in severity and may require monitoring and management by your healthcare provider.
Alpelisib can cause severe skin reactions, high blood sugar, and diarrhea, which require immediate medical attention. It is not recommended for people with severe liver problems or known allergies to the medication.
Indications and Purpose
How does Alpelisib work?
Alpelisib works by blocking a protein called PI3K, which helps cancer cells grow and survive. Think of it like turning off a switch that cancer cells need to multiply. By inhibiting this protein, Alpelisib slows down the growth of cancer cells and can shrink tumors. This action helps manage certain types of breast cancer, especially in patients with specific genetic mutations. Alpelisib is often used in combination with other therapies to enhance its effectiveness in treating cancer.
Is Alpelisib effective?
Alpelisib is effective in treating certain types of breast cancer. It works by blocking a protein that helps cancer cells grow. Clinical studies show that Alpelisib can slow the progression of cancer and improve survival rates in patients with specific genetic mutations. The effectiveness of Alpelisib depends on the individual's cancer type and genetic profile. Your doctor will monitor your response to the medication through regular check-ups and tests to ensure it's working effectively for your condition.
What is Alpelisib?
Alpelisib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called PI3K inhibitors, which work by blocking a protein that helps cancer cells grow. Alpelisib is used in combination with other therapies to slow the progression of cancer in patients with specific genetic mutations. It helps manage cancer by targeting the pathways that cancer cells use to multiply. Your doctor will determine if Alpelisib is appropriate for your treatment based on your cancer type and genetic profile.
Directions for Use
For how long do I take Alpelisib?
Alpelisib is usually taken long-term for managing certain types of breast cancer. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will monitor your progress and adjust your treatment plan as needed. It's important to follow your doctor's instructions and not stop taking Alpelisib without medical advice. Regular check-ups with your healthcare provider will help determine how long you should continue taking the medication.
How do I dispose of Alpelisib?
To dispose of Alpelisib, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. Always keep medications out of reach of children and pets.
How do I take Alpelisib?
Take Alpelisib exactly as your doctor prescribes. It's usually taken once daily with food to help reduce stomach upset. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking Alpelisib, as they can affect how the medicine works. Always follow your doctor's specific instructions regarding your medication.
How long does it take for Alpelisib to start working?
Alpelisib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on your cancer type and individual response to the medication. Regular check-ups and tests with your doctor will help monitor your progress and determine how well Alpelisib is working for you. It's important to take the medication exactly as prescribed for the best results.
How should I store Alpelisib?
Store Alpelisib at room temperature, between 68°F to 77°F, in a tightly closed container. Protect it from moisture and light, which can damage the medication. Avoid storing it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always keep Alpelisib out of reach of children and pets. Regularly check the expiration date and properly dispose of any unused or expired medication.
What is the usual dose of Alpelisib?
The usual starting dose of Alpelisib for adults is 300 mg taken once daily with food. Your doctor may adjust your dose based on how you respond to the treatment and any side effects you experience. The maximum recommended dose is 300 mg per day. Alpelisib is not typically used in children, and elderly patients may require careful monitoring. Always follow your doctor's specific dosing instructions for your health needs, and do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can Alpelisib be taken safely while breastfeeding?
Alpelisib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk. However, due to potential risks to the infant, it's best to avoid using Alpelisib while nursing. The medication might affect the baby's development or health. If you're taking Alpelisib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Alpelisib be taken safely while pregnant?
Alpelisib is not recommended during pregnancy. There is limited evidence on its safety for pregnant women. Animal studies suggest potential harm to the developing fetus. Using Alpelisib during pregnancy could lead to birth defects or other complications. If you are pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a treatment plan that protects both you and your baby during this important time.
Can I take Alpelisib with other prescription drugs?
Alpelisib can interact with other medications, increasing the risk of side effects or reducing its effectiveness. For example, drugs that affect liver enzymes, like certain antifungals and antibiotics, can alter Alpelisib levels in your body. This can lead to increased side effects or reduced effectiveness. Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan if necessary.
Does Alpelisib have adverse effects?
Adverse effects are unwanted reactions to a medication. Alpelisib can cause several adverse effects, including high blood sugar, diarrhea, and skin rash. These effects vary in frequency and severity. High blood sugar is common and requires monitoring. Diarrhea can be managed with hydration and diet changes. Skin rash may need medical attention if severe. Rare but serious effects include severe allergic reactions. Always inform your doctor about any new or worsening symptoms while taking Alpelisib. They can help manage these effects and adjust your treatment if necessary.
Does Alpelisib have any safety warnings?
Yes, Alpelisib comes with important safety warnings. It can cause severe skin reactions, high blood sugar, and diarrhea. These conditions require immediate medical attention. Not following these warnings can lead to serious health issues. For example, untreated high blood sugar can cause diabetic ketoacidosis, which is a dangerous buildup of acids in your blood. Always follow your doctor's advice and report any unusual symptoms promptly. Regular monitoring and communication with your healthcare provider are crucial while taking Alpelisib.
Is Alpelisib addictive?
Alpelisib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Alpelisib works by targeting specific cancer cells and does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Alpelisib doesn't carry this risk while managing your cancer treatment.
Is Alpelisib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Alpelisib, such as high blood sugar and dehydration. These risks require careful monitoring. Alpelisib is generally safe for elderly patients, but they may experience more pronounced side effects. Regular check-ups and communication with your healthcare provider are important to manage these risks. Your doctor may adjust your dose or suggest additional monitoring to ensure your treatment is safe and effective.
Is it safe to drink alcohol while taking Alpelisib?
It's best to avoid alcohol while taking Alpelisib. Alcohol can increase the risk of side effects like nausea and liver problems. It may also interfere with how Alpelisib works in your body. Drinking alcohol can worsen dehydration, which is a concern with Alpelisib. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs like dizziness or stomach pain. Talk with your doctor about alcohol use while taking Alpelisib for personalized advice.
Is it safe to exercise while taking Alpelisib?
You can exercise while taking Alpelisib, but be mindful of potential side effects. Alpelisib can cause fatigue and dehydration, which might affect your exercise capacity. During physical activity, you might feel dizzy or lightheaded, especially in hot weather. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns about your exercise routine.
Is it safe to stop Alpelisib?
Stopping Alpelisib suddenly can affect your cancer treatment. It's usually used long-term for managing cancer. Stopping without medical advice can lead to cancer progression. There are no specific withdrawal symptoms, but your condition may worsen. Always talk with your doctor before stopping Alpelisib. They might suggest a gradual reduction or an alternative treatment to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Alpelisib?
Side effects are unwanted reactions to a medication. Common side effects of Alpelisib include high blood sugar, diarrhea, and rash. These occur in more than 10% of patients. High blood sugar can lead to symptoms like increased thirst and urination. Diarrhea may cause dehydration, so staying hydrated is important. Rash can vary in severity. If you experience these side effects, they might be temporary or unrelated to Alpelisib. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Alpelisib and suggest ways to manage them.
Who should avoid taking Alpelisib?
Alpelisib should not be used if you have a known allergy to it or its ingredients. This is an absolute contraindication. Serious allergic reactions require immediate medical help. Alpelisib is also not recommended for people with severe liver problems, as it can worsen liver function. Use caution if you have a history of diabetes, as Alpelisib can raise blood sugar levels. Always consult your doctor about these concerns before starting Alpelisib to ensure it's safe for you.
