Alosetron
Abdominal Pain, Irritable Bowel Syndrome ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Serotonin-3 Receptor Antagonist
Controlled Drug Substance
NO
Alosetron
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Click HereSummary
Alosetron is used to treat severe diarrhea-predominant irritable bowel syndrome (IBS) in women who have not responded to other treatments.
Alosetron works by blocking serotonin (5-HT3) receptors. This slows the movement of stool through the intestines, reducing symptoms like diarrhea, abdominal pain, and urgency.
Alosetron is typically prescribed as 0.5 mg taken twice a day. If symptoms are not adequately controlled, the dose may be increased to 1 mg twice a day after 4 weeks.
Common side effects include constipation, abdominal discomfort and pain, nausea, and gastrointestinal discomfort. Serious adverse effects include ischemic colitis and severe constipation.
Alosetron should not be taken by patients with a history of severe bowel or hepatic disorders, or those taking fluvoxamine. It can cause serious gastrointestinal side effects, including ischemic colitis and severe constipation, which can be life-threatening.
Indications and Purpose
What is Alosetron used for?
Alosetron is indicated for the treatment of severe diarrhea-predominant irritable bowel syndrome (IBS) in women who have not responded to conventional therapy.
How does Alosetron work?
Alosetron is a 5-HT3 receptor antagonist that slows the movement of stool through the intestines, reducing symptoms of diarrhea and abdominal pain associated with IBS.
Is Alosetron effective?
Alosetron has been shown to be effective in women with severe diarrhea-predominant IBS who have not responded to conventional therapy. Clinical studies have demonstrated its ability to reduce symptoms such as abdominal pain, diarrhea, and bowel urgency.
How does one know if Alosetron is working?
The benefit of Alosetron is evaluated by assessing the control of IBS symptoms after 4 weeks of treatment. If symptoms are not adequately controlled, the medication may be discontinued.
Directions for Use
What is the usual dose of Alosetron?
The usual daily dose for adults is 0.5 mg twice a day, which may be increased to 1 mg twice a day if needed. Alosetron is not recommended for use in children.
How do I take Alosetron?
Alosetron should be taken twice a day, with or without food, at the same times each day. There are no specific food restrictions, but follow your doctor's instructions carefully.
For how long do I take Alosetron?
Alosetron is typically used for a duration of 4 weeks to assess its effectiveness. If symptoms are not controlled after this period, it is unlikely to be beneficial.
How long does it take for Alosetron to start working?
Alosetron may start to relieve symptoms within a few days, but it is typically evaluated for effectiveness after 4 weeks of use.
How should I store Alosetron?
Store Alosetron in its original container, tightly closed, at room temperature away from light, excess heat, and moisture. Keep it out of reach of children and do not store it in the bathroom.
Warnings and Precautions
Who should avoid taking Alosetron?
Alosetron can cause serious gastrointestinal side effects, including ischemic colitis and severe constipation, which may require hospitalization. It is contraindicated in patients with a history of severe bowel or hepatic disorders, and those taking fluvoxamine.
Can I take Alosetron with other prescription drugs?
Alosetron should not be taken with fluvoxamine, a strong inhibitor of CYP1A2, as it can significantly increase Alosetron levels. Caution is advised with other CYP1A2 inhibitors like cimetidine and ketoconazole.
Can I take Alosetron with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Alosetron be taken safely while pregnant?
There is insufficient data on the use of Alosetron during pregnancy to draw conclusions about risks. It should be used only if clearly needed, and the potential benefits justify the potential risks to the fetus.
Can Alosetron be taken safely while breastfeeding?
There is no data on the presence of Alosetron in human milk. If breastfeeding while taking Alosetron, monitor the infant for constipation or bloody stools, and consult a doctor for advice.
Is Alosetron safe for the elderly?
Elderly patients may be at greater risk for complications of constipation when using Alosetron. Therefore, appropriate caution and follow-up should be exercised if Alosetron is prescribed for these patients.
Is it safe to exercise while taking Alosetron?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Alosetron?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.