Almotriptan
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Serotonin-1b and Serotonin-1d Receptor Agonist
Controlled Drug Substance
NO
Almotriptan
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Click HereSummary
Almotriptan is used to treat acute migraine attacks in adults and adolescents aged 12 to 17 years. It is not intended for migraine prevention or for treating other types of headaches such as cluster headaches.
Almotriptan works by binding to serotonin receptors in the brain. This action helps narrow blood vessels and reduce the release of substances that cause pain and other migraine symptoms, thereby alleviating the headache and associated symptoms like nausea and sensitivity to light and sound.
For adults and adolescents aged 12 to 17 years, the recommended dose of Almotriptan is 6.25 mg to 12.5 mg, with a maximum daily dose not exceeding 25 mg. It should be taken at the first sign of a migraine.
Common side effects of Almotriptan include nausea, dizziness, and drowsiness. Serious adverse effects can include cardiovascular events like heart attack or stroke, though these are rare.
Almotriptan is contraindicated in individuals with a history of heart disease, stroke, uncontrolled hypertension, and certain types of migraines. It should not be used with other triptans or ergotamine medications within 24 hours. Patients should be aware of the risk of serious cardiovascular events.
Indications and Purpose
What is Almotriptan used for?
Almotriptan is indicated for the acute treatment of migraine attacks in adults and adolescents aged 12 to 17 years, with or without aura. It is not intended for the prevention of migraines or for use in managing hemiplegic or basilar migraines.
How does Almotriptan work?
Almotriptan works by binding to serotonin receptors in the brain, which helps narrow blood vessels and reduce inflammation. This action stops pain signals from being sent to the brain and blocks the release of substances that cause migraine symptoms.
Is Almotriptan effective?
The efficacy of Almotriptan in treating migraine attacks has been established in multiple clinical trials. In these studies, a significant percentage of patients reported pain relief within two hours of taking the medication compared to those who received a placebo. Almotriptan also helped reduce associated symptoms like nausea and sensitivity to light and sound.
How does one know if Almotriptan is working?
The benefit of Almotriptan is evaluated by its ability to relieve migraine headache pain and associated symptoms within two hours of administration. Patients are advised to keep a headache diary to track the frequency and severity of headaches and the effectiveness of the medication.
Directions for Use
What is the usual dose of Almotriptan?
For adults, the recommended dose of Almotriptan is 6.25 mg to 12.5 mg, with the 12.5 mg dose being more effective. For adolescents aged 12 to 17 years, the same dosage range applies. The maximum daily dose should not exceed 25 mg.
How do I take Almotriptan?
Almotriptan can be taken with or without food. It should be taken at the first sign of a migraine headache. There are no specific food restrictions, but it is advised to discuss any dietary concerns with your doctor.
For how long do I take Almotriptan?
Almotriptan is used for the acute treatment of migraine attacks and should be taken at the first sign of a migraine. It is not intended for long-term use or prevention of migraines. The safety of treating more than four migraines in a 30-day period has not been established.
How long does it take for Almotriptan to start working?
Almotriptan typically starts working within 1 to 3 hours after administration, providing relief from migraine headache pain and associated symptoms.
How should I store Almotriptan?
Almotriptan should be stored at room temperature, away from excess heat and moisture. It should be kept in its original container, tightly closed, and out of reach of children. Unused medication should be disposed of properly, preferably through a medicine take-back program.
Warnings and Precautions
Who should avoid taking Almotriptan?
Almotriptan should not be used by individuals with a history of heart disease, stroke, or uncontrolled hypertension. It is also contraindicated in patients with hemiplegic or basilar migraine. Almotriptan should not be taken within 24 hours of other triptans or ergotamine medications. Patients with risk factors for cardiovascular disease should be evaluated before use.
Can I take Almotriptan with other prescription drugs?
Almotriptan should not be taken with other triptans or ergotamine medications within 24 hours due to the risk of additive vasospastic effects. Caution is advised when used with SSRIs or SNRIs due to the risk of serotonin syndrome. Potent CYP3A4 inhibitors may increase Almotriptan exposure, requiring dose adjustments.
Can I take Almotriptan with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Almotriptan be taken safely while pregnant?
Almotriptan is categorized as Pregnancy Category C, indicating that there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for personalized advice.
Can Almotriptan be taken safely while breastfeeding?
It is not known whether Almotriptan is excreted in human milk. Caution should be exercised when administering to nursing mothers. Consult your doctor to discuss the potential risks and benefits before using Almotriptan while breastfeeding.
Is Almotriptan safe for the elderly?
For elderly patients, Almotriptan should be used with caution, especially if there is a history of cardiovascular disease. Dose selection should be cautious, usually starting at the lower end of the dosing range, due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Is it safe to exercise while taking Almotriptan?
Almotriptan may cause drowsiness or dizziness, which could affect your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. If you feel unwell or dizzy, it is best to avoid strenuous exercise and consult your doctor.
Is it safe to drink alcohol while taking Almotriptan?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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