Aliskiren
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Renin Inhibitor
Controlled Drug Substance
NO
Aliskiren
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Click HereSummary
Aliskiren is used for the long-term management of high blood pressure in adults and children aged 6 years and older who weigh 50 kg or more. It helps reduce the risk of cardiovascular events like strokes and heart attacks.
Aliskiren is a direct renin inhibitor. It decreases plasma renin activity, which reduces the conversion of angiotensinogen to angiotensin I. This results in lower levels of angiotensin II, a substance that narrows blood vessels. So, blood vessels relax and blood pressure is lowered.
The usual starting dose for adults and children aged 6 years and older weighing 50 kg or more is 150 mg once daily. This may be increased to 300 mg once daily if needed.
Common side effects include diarrhea, headache, and dizziness. Serious adverse effects can include angioedema, renal impairment, and high levels of potassium in the blood (hyperkalemia).
Aliskiren should not be used during pregnancy or while breastfeeding. It is also contraindicated in patients with diabetes taking ARBs or ACEIs due to an increased risk of renal impairment and hyperkalemia. Patients with a history of angioedema should use it cautiously.
Indications and Purpose
What is Aliskiren used for?
Aliskiren is indicated for the treatment of hypertension in adults and children aged 6 years and older weighing 50 kg or more. Lowering blood pressure helps reduce the risk of cardiovascular events such as strokes and heart attacks.
How does Aliskiren work?
Aliskiren is a direct renin inhibitor that decreases plasma renin activity, reducing the conversion of angiotensinogen to angiotensin I. This leads to lower levels of angiotensin II, a powerful vasoconstrictor, resulting in relaxed blood vessels and lower blood pressure.
Is Aliskiren effective?
Aliskiren is effective in lowering blood pressure, as demonstrated in several clinical trials. It reduces both systolic and diastolic blood pressure, which helps lower the risk of cardiovascular events like strokes and heart attacks. However, there are no controlled trials specifically showing risk reduction with Aliskiren.
How does one know if Aliskiren is working?
The benefit of Aliskiren is evaluated through regular monitoring of blood pressure and periodic lab tests to check renal function and electrolyte levels. Keep all appointments with your doctor to ensure the medication is working effectively and safely.
Directions for Use
What is the usual dose of Aliskiren?
For adults, the usual starting dose of Aliskiren is 150 mg once daily, which may be increased to 300 mg once daily if needed. For children aged 6 years and older weighing 50 kg or more, the same dosage applies. Aliskiren is not recommended for children under 6 years of age or those weighing less than 50 kg.
How do I take Aliskiren?
Take Aliskiren once daily, either always with food or always without food, at the same time each day. Avoid high-fat meals as they can decrease absorption. Do not use salt substitutes containing potassium without consulting your doctor.
For how long do I take Aliskiren?
Aliskiren is used for long-term management of high blood pressure. It is important to continue taking it even if you feel well, as it controls but does not cure high blood pressure. Always follow your doctor's instructions regarding the duration of use.
How long does it take for Aliskiren to start working?
Aliskiren's antihypertensive effect is substantially attained within 2 weeks, with 85% to 90% of the effect observed. However, it may take longer for some individuals to experience the full benefits.
How should I store Aliskiren?
Store Aliskiren in its original container, tightly closed, at room temperature away from excess heat and moisture. Do not store it in the bathroom. Keep it out of reach of children and do not remove the desiccant from the bottle if provided.
Warnings and Precautions
Who should avoid taking Aliskiren?
Aliskiren should not be used during pregnancy as it can harm the fetus. It is contraindicated in patients with diabetes who are taking ARBs or ACEIs due to increased risk of renal impairment and hyperkalemia. Patients with a history of angioedema should use it cautiously. Consult your doctor for personalized advice.
Can I take Aliskiren with other prescription drugs?
Aliskiren should not be used with ARBs or ACEIs in patients with diabetes due to increased risk of renal impairment and hyperkalemia. Avoid using it with cyclosporine or itraconazole as they increase Aliskiren levels. NSAIDs may reduce its effectiveness and increase renal risk.
Can I take Aliskiren with vitamins or supplements?
Avoid potassium supplements or salt substitutes containing potassium while taking Aliskiren, as they can increase the risk of hyperkalemia. Always consult your doctor before starting any new vitamins or supplements.
Can Aliskiren be taken safely while pregnant?
Aliskiren is contraindicated during pregnancy as it can cause fetal harm, including injury and death. If pregnancy is detected, discontinue Aliskiren immediately. There is strong evidence that drugs affecting the renin-angiotensin system can harm the developing fetus.
Can Aliskiren be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Aliskiren due to the potential for serious adverse reactions in nursing infants, including hypotension and renal impairment. Consult your doctor for alternative treatments if you are breastfeeding.
Is Aliskiren safe for the elderly?
Elderly patients may have increased exposure to Aliskiren, but no overall differences in safety or effectiveness have been observed compared to younger patients. However, greater sensitivity in some older individuals cannot be ruled out. Regular monitoring by a healthcare provider is recommended.
Is it safe to exercise while taking Aliskiren?
Aliskiren does not typically limit the ability to exercise. However, if you experience symptoms like dizziness or lightheadedness, it may be best to avoid strenuous activities and consult your doctor for advice.
Is it safe to drink alcohol while taking Aliskiren?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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