Alectinib
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Alectinib
Summary
Alectinib is used to treat a type of lung cancer known as ALK-positive non-small cell lung cancer (NSCLC) that has spread to other parts of the body. It's also used after tumor removal to prevent cancer recurrence in patients with ALK-positive NSCLC.
Alectinib is a tyrosine kinase inhibitor. It blocks the action of an abnormal protein that signals cancer cells to multiply. This helps to slow or stop the spread of cancer cells.
The usual daily dose for adults is 600 mg taken orally twice daily with food. It's not recommended for children as its safety and effectiveness in pediatric patients have not been established.
Common side effects include constipation, fatigue, muscle pain, swelling, rash, and cough. Serious adverse effects include liver problems, lung inflammation, kidney issues, slow heart rate, and a type of anemia where your body destroys too many red blood cells.
Alectinib may cause liver problems, lung inflammation, kidney issues, slow heart rate, muscle pain, and a type of anemia. These conditions should be monitored and treatment may need to be adjusted if they occur. There are no specific contraindications listed, but you should inform your doctor of any allergies or medical conditions.
Indications and Purpose
How does Alectinib work?
Alectinib works by blocking a protein called ALK, which helps cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By inhibiting this protein, Alectinib slows down the progression of non-small cell lung cancer. This helps improve survival rates and manage symptoms in patients with this type of cancer.
Is Alectinib effective?
Alectinib is effective in treating non-small cell lung cancer, which is a type of lung cancer. It works by blocking proteins that help cancer cells grow. Clinical studies show Alectinib can significantly slow cancer progression and improve survival rates in patients with this type of cancer. Your doctor will monitor your response to the medication to ensure it's working effectively for you.
What is Alectinib?
Alectinib is a medication used to treat non-small cell lung cancer, which is a type of lung cancer. It belongs to a class of drugs called ALK inhibitors, which work by blocking proteins that help cancer cells grow. Alectinib is used when the cancer has spread to other parts of the body and is often prescribed when other treatments haven't worked. It helps slow cancer progression and improve survival rates.
Directions for Use
For how long do I take Alectinib?
Alectinib is usually a long-term medication for managing non-small cell lung cancer. You'll typically take Alectinib every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Alectinib treatment.
How do I dispose of Alectinib?
Dispose of Alectinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent harm to people and the environment.
How do I take Alectinib?
Take Alectinib as prescribed by your doctor, usually twice daily with food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's within 6 hours of your next dose. In that case, skip the missed dose. Avoid taking two doses at once. Follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Alectinib to start working?
Alectinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and how your body responds to the medication. Regular check-ups with your doctor will help monitor your progress and adjust your treatment as needed.
How should I store Alectinib?
Store Alectinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms. Always keep Alectinib out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Alectinib?
The usual starting dose of Alectinib for adults is 600 mg taken twice daily with food. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Alectinib be taken safely while breastfeeding?
Alectinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to the baby. If you're taking Alectinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Alectinib be taken safely while pregnant?
Alectinib is not recommended during pregnancy due to potential harm to the unborn baby. There is limited evidence on its safety during pregnancy, but animal studies suggest risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. Your doctor can help create a plan that protects both you and your baby.
Can I take Alectinib with other prescription drugs?
Alectinib can interact with certain medications, increasing the risk of side effects or reducing its effectiveness. Avoid using strong CYP3A inhibitors or inducers, as they can affect Alectinib levels in your body. Always inform your doctor about all medications you're taking to prevent interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does Alectinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Alectinib include fatigue, constipation, and swelling in the hands or feet. These effects vary in frequency and severity. Serious side effects include liver problems and lung inflammation. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these are related to Alectinib and suggest appropriate actions.
Does Alectinib have any safety warnings?
Alectinib has important safety warnings. It can cause liver problems, which may lead to liver failure. Signs include yellowing of the skin or eyes, dark urine, or severe fatigue. Alectinib can also cause lung inflammation, leading to breathing difficulties. If you experience these symptoms, seek medical help immediately. Regular monitoring by your doctor is essential to manage these risks.
Is Alectinib addictive?
Alectinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Alectinib works by targeting specific proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Alectinib doesn't carry this risk.
Is Alectinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Alectinib, such as liver problems or fatigue. However, Alectinib can be used safely in the elderly with careful monitoring by a healthcare provider. Regular check-ups are important to manage any potential risks and ensure the medication is working effectively. Discuss any concerns with your doctor.
Is it safe to drink alcohol while taking Alectinib?
It's best to avoid alcohol while taking Alectinib. Alcohol can increase the risk of liver problems, which is a potential side effect of Alectinib. Drinking alcohol may also worsen other side effects like dizziness or fatigue. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking Alectinib.
Is it safe to exercise while taking Alectinib?
You can exercise while taking Alectinib, but be mindful of your body's response. Alectinib can cause fatigue or dizziness, which might affect your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Drink plenty of water and rest if you experience dizziness or unusual fatigue. Consult your doctor if you have concerns about exercising while on Alectinib.
Is it safe to stop Alectinib?
Stopping Alectinib suddenly can cause your cancer to progress. It's important to follow your doctor's instructions and not stop taking Alectinib without medical advice. Your doctor may suggest gradually reducing your dose or switching to a different medication to manage your condition safely. Always talk with your doctor before making any changes to your medication regimen.
What are the most common side effects of Alectinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Alectinib include fatigue, constipation, and swelling in the hands or feet. These effects vary from person to person. If you notice new symptoms after starting Alectinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Alectinib?
Don't take Alectinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Alectinib is not recommended for use during pregnancy or breastfeeding due to potential harm to the baby. Always consult your doctor about any concerns or conditions that might affect your use of Alectinib.
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