Aceclofenac + Rabeprazole

Find more information about this combination medication at the webpages for rabeprazole and aceclofenac

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Brand Name

Instaflex Ar Capsules 10s , Freenac RB 200mg/20mg Tablet 10s ... show more

Approved Treatment Indication:

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This medicine contains a combination of 2 drugs aceclofenac and rabeprazole.
Each of these drugs treats a different disease or symptom.
Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions aceclofenac and rabeprazole is used for
Aceclofenac is used to relieve pain and inflammation in conditions like arthritis, which is a disease causing joint pain and swelling. Rabeprazole is used to reduce stomach acid in conditions like GERD, which is a chronic acid reflux disease. Together, they help manage pain from inflammatory conditions while protecting the stomach from irritation caused by NSAIDs, which are drugs that reduce inflammation and pain.
How aceclofenac and rabeprazole works in the body
Aceclofenac works by blocking prostaglandins, which are chemicals causing pain and inflammation. This helps reduce swelling and pain. Rabeprazole works by inhibiting the proton pump, which is a part of the stomach lining that produces acid. This reduces stomach acid, preventing and healing acid-related damage. Together, they provide pain relief while protecting the stomach from irritation.
The usual dosages and routes of administration of aceclofenac and rabeprazole
The usual adult dose for aceclofenac is 100 mg taken twice daily, which helps manage pain and inflammation. Rabeprazole is commonly dosed at 20 mg once daily, which helps reduce stomach acid production. Both medications are taken orally, which means they are swallowed by mouth. Dosages may vary based on individual health conditions and should follow a healthcare provider's instructions.
The most commonly observed adverse effects of aceclofenac and rabeprazole
Common side effects of aceclofenac include stomach pain, nausea, and diarrhea, which are related to its action as an NSAID. Rabeprazole may cause headache, dizziness, and diarrhea due to its role in reducing stomach acid. Both medicines can cause allergic reactions, which are rare but serious. Monitoring for side effects is important to ensure safe use.
Important safety warnings and contraindications of aceclofenac and rabeprazole
Aceclofenac should not be used by individuals with a history of gastrointestinal bleeding or severe heart failure, which is a condition where the heart can't pump blood effectively. Rabeprazole is contraindicated in people with known hypersensitivity to PPIs, which are drugs that reduce stomach acid. Both should be used cautiously in individuals with liver or kidney problems. Avoid alcohol with aceclofenac to reduce stomach bleeding risk.

Government Approvals

UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

None

Controlled Drug Substance

Summary

What conditions aceclofenac and rabeprazole is used for
Aceclofenac is used to relieve pain and inflammation in conditions like arthritis, which is a disease causing joint pain and swelling. Rabeprazole is used to reduce stomach acid in conditions like GERD, which is a chronic acid reflux disease. Together, they help manage pain from inflammatory conditions while protecting the stomach from irritation caused by NSAIDs, which are drugs that reduce inflammation and pain.
How aceclofenac and rabeprazole works in the body
Aceclofenac works by blocking prostaglandins, which are chemicals causing pain and inflammation. This helps reduce swelling and pain. Rabeprazole works by inhibiting the proton pump, which is a part of the stomach lining that produces acid. This reduces stomach acid, preventing and healing acid-related damage. Together, they provide pain relief while protecting the stomach from irritation.
The usual dosages and routes of administration of aceclofenac and rabeprazole
The usual adult dose for aceclofenac is 100 mg taken twice daily, which helps manage pain and inflammation. Rabeprazole is commonly dosed at 20 mg once daily, which helps reduce stomach acid production. Both medications are taken orally, which means they are swallowed by mouth. Dosages may vary based on individual health conditions and should follow a healthcare provider's instructions.
The most commonly observed adverse effects of aceclofenac and rabeprazole
Common side effects of aceclofenac include stomach pain, nausea, and diarrhea, which are related to its action as an NSAID. Rabeprazole may cause headache, dizziness, and diarrhea due to its role in reducing stomach acid. Both medicines can cause allergic reactions, which are rare but serious. Monitoring for side effects is important to ensure safe use.
Important safety warnings and contraindications of aceclofenac and rabeprazole
Aceclofenac should not be used by individuals with a history of gastrointestinal bleeding or severe heart failure, which is a condition where the heart can't pump blood effectively. Rabeprazole is contraindicated in people with known hypersensitivity to PPIs, which are drugs that reduce stomach acid. Both should be used cautiously in individuals with liver or kidney problems. Avoid alcohol with aceclofenac to reduce stomach bleeding risk.

Indications and Purpose

How does combination of aceclofenac and rabeprazole work?

Aceclofenac works by blocking the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. This action helps reduce symptoms like swelling and pain. Rabeprazole works by inhibiting the proton pump in the stomach lining, which reduces the production of stomach acid. This helps prevent and heal acid-related damage to the stomach and esophagus. Together, they provide pain relief while protecting the stomach from irritation, offering a balanced approach to managing conditions that require both pain control and stomach protection.

How does combination of Aceclofenac and Rabeprazole work?

Aceclofenac is a non-steroidal anti-inflammatory drug, which means it helps reduce inflammation and pain in the body. It works by blocking the production of certain chemicals called prostaglandins, which are responsible for causing pain and swelling. This makes it effective for conditions like arthritis. Rabeprazole, on the other hand, is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. It works by blocking the enzyme in the stomach lining that produces acid, helping to relieve symptoms of acid reflux and prevent ulcers. Both Aceclofenac and Rabeprazole are used to manage pain and discomfort, but they do so in different ways. While Aceclofenac targets inflammation, Rabeprazole focuses on reducing stomach acid. They are often used together to manage pain while protecting the stomach from irritation caused by anti-inflammatory drugs.

How effective is combination of aceclofenac and rabeprazole?

Evidence for aceclofenac's effectiveness comes from clinical trials showing its ability to reduce pain and inflammation in conditions like arthritis. Rabeprazole has been proven effective in reducing stomach acid and treating conditions like GERD, which stands for gastroesophageal reflux disease. When used together, studies indicate that the combination effectively manages pain while minimizing the risk of stomach ulcers, which are sores in the stomach lining. This dual action is supported by research showing improved patient outcomes in terms of pain relief and gastrointestinal protection.

How effective is combination of Aceclofenac and Rabeprazole?

Aceclofenac is a non-steroidal anti-inflammatory drug, which means it helps reduce inflammation and pain in conditions like arthritis. It works by blocking the production of certain chemicals in the body that cause inflammation. Rabeprazole, on the other hand, is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach, helping with conditions like acid reflux and ulcers. Both Aceclofenac and Rabeprazole are effective in their respective roles, with evidence showing they relieve symptoms associated with inflammation and excess stomach acid. A common attribute they share is their ability to improve quality of life by alleviating discomfort. However, they work in different ways and are used for different conditions. Aceclofenac targets pain and inflammation, while Rabeprazole focuses on reducing stomach acid.

Directions for Use

What is the usual dose of combination of aceclofenac and rabeprazole?

The usual adult dose for aceclofenac is typically 100 mg taken twice daily, which helps manage pain and inflammation. For rabeprazole, the common dose is 20 mg once daily, which helps reduce stomach acid production. These dosages may vary based on individual health conditions and the specific needs of the patient. It's important to follow the healthcare provider's instructions and not to exceed the recommended dose to avoid potential side effects and ensure the medicines work effectively.

What is the usual dose of combination of Aceclofenac and Rabeprazole?

The usual adult daily dose for Aceclofenac, which is a non-steroidal anti-inflammatory drug used to relieve pain and inflammation, is typically 100 mg taken twice a day. On the other hand, Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, is usually taken at a dose of 20 mg once a day. Aceclofenac works by blocking the production of substances in the body that cause inflammation and pain, while Rabeprazole works by reducing the amount of acid produced in the stomach. Both medications are used to treat conditions that involve pain and discomfort, but they do so in different ways. They share the common attribute of being taken orally and are often used to manage symptoms related to inflammation and acid-related issues.

How does one take combination of aceclofenac and rabeprazole?

Aceclofenac is best taken with food to minimize stomach irritation, while rabeprazole can be taken with or without food, but it's often recommended to take it before meals for optimal acid reduction. It's important to avoid alcohol while taking aceclofenac, as it can increase the risk of stomach bleeding. Patients should follow their healthcare provider's instructions regarding food intake and any specific dietary restrictions to ensure the medicines work effectively and safely.

How does one take combination of Aceclofenac and Rabeprazole?

Aceclofenac, which is a non-steroidal anti-inflammatory drug used to relieve pain and inflammation, is usually taken with food to reduce the risk of stomach upset. Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, can be taken with or without food, but it is often recommended to take it before meals for best results. Both medications may have interactions with certain foods or substances, so it's important to follow your healthcare provider's advice. While Aceclofenac can cause stomach irritation, Rabeprazole helps protect the stomach lining, which is why they are sometimes prescribed together. Always consult your doctor or pharmacist for personalized advice and to understand any specific dietary restrictions you should follow while taking these medications.

For how long is combination of aceclofenac and rabeprazole taken?

The duration of use for aceclofenac depends on the condition being treated, but it is generally used for short-term relief of pain and inflammation. Rabeprazole may be used for a longer duration, especially in chronic conditions like GERD, to manage stomach acid levels. The combination's duration should be determined by a healthcare provider, who will consider the patient's specific needs and response to treatment. It's important to follow the prescribed duration to avoid potential side effects and ensure effective management of symptoms.

For how long is combination of Aceclofenac and Rabeprazole taken?

Aceclofenac is typically used for short-term relief of pain and inflammation, which refers to swelling and redness, often associated with conditions like arthritis. The duration of use can vary depending on the condition being treated, but it is generally not recommended for long-term use due to potential side effects. Rabeprazole is used to treat conditions like acid reflux, which is a condition where stomach acid flows back into the esophagus, and ulcers, which are sores on the stomach lining. It is often prescribed for a longer duration, sometimes several weeks to months, depending on the condition. Both medicines are used to manage symptoms and improve quality of life. They share the common goal of providing relief from discomfort, but they work in different ways and are used for different conditions. Always follow a healthcare provider's guidance on how long to use these medications.

How long does it take for combination of aceclofenac and rabeprazole to work?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID), typically starts working within 30 minutes to an hour to relieve pain and inflammation. Rabeprazole, which is a proton pump inhibitor (PPI), may take a bit longer, usually a few hours, to start reducing stomach acid production. Together, this combination medicine can provide pain relief relatively quickly while also protecting the stomach lining from irritation caused by NSAIDs. The combination ensures that while aceclofenac addresses pain and inflammation, rabeprazole helps prevent stomach-related side effects.

How long does it take for combination of Aceclofenac and Rabeprazole to work?

The time it takes for a combination medicine to start working depends on the individual medicines it contains. For example, if the combination includes ibuprofen, which is a pain reliever and anti-inflammatory, it typically starts working within 20 to 30 minutes. If it includes paracetamol, which is another pain reliever, it usually begins to work within 30 to 60 minutes. Both medicines are used to relieve pain and reduce fever, which means they share these common attributes. However, ibuprofen also reduces inflammation, which is swelling and redness, while paracetamol does not. When combined, these medicines can provide a broader range of relief, addressing both pain and inflammation more effectively. Always follow the dosage instructions provided by your healthcare provider or the medicine's packaging.

Warnings and Precautions

Are there harms and risks from taking combination of aceclofenac and rabeprazole?

Common side effects of aceclofenac include stomach pain, nausea, and diarrhea, which are related to its action as an NSAID. Rabeprazole may cause side effects like headache, dizziness, and diarrhea due to its role in reducing stomach acid. Significant adverse effects of aceclofenac can include gastrointestinal bleeding and kidney issues, while rabeprazole may lead to vitamin B12 deficiency with long-term use. Both medicines can cause allergic reactions, which are rare but serious. Together, they aim to balance pain relief with stomach protection, but monitoring for side effects is important.

Are there harms and risks from taking combination of Aceclofenac and Rabeprazole?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID), is commonly used to relieve pain and inflammation. Its common side effects include stomach pain, nausea, and diarrhea. Significant adverse effects can include gastrointestinal bleeding, which refers to bleeding in the digestive tract, and kidney problems. Rabeprazole, which is a proton pump inhibitor (PPI), is used to reduce stomach acid. Common side effects include headache, diarrhea, and dizziness. Significant adverse effects can include severe allergic reactions and liver problems. Both medications can cause gastrointestinal issues like diarrhea, but they have unique attributes. Aceclofenac is primarily used for pain relief, while Rabeprazole is used to manage stomach acid. It's important to use these medications as directed by a healthcare provider to minimize risks.

Can I take combination of aceclofenac and rabeprazole with other prescription drugs?

Aceclofenac can interact with blood thinners like warfarin, increasing the risk of bleeding. It may also interact with other NSAIDs, enhancing side effects. Rabeprazole can interact with drugs like methotrexate, increasing its levels and potential toxicity. Both medicines can affect the absorption of certain drugs, like antifungals and HIV medications, due to changes in stomach acidity. It's crucial to inform healthcare providers of all medications being taken to manage potential interactions and adjust treatment plans accordingly.

Can I take combination of Aceclofenac and Rabeprazole with other prescription drugs?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID), can interact with other medications that increase the risk of bleeding, such as blood thinners like warfarin. It may also interact with other NSAIDs, increasing the risk of side effects like stomach ulcers. Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, can interact with drugs that require stomach acid for absorption, such as certain antifungal medications. Both Aceclofenac and Rabeprazole can affect the liver, so caution is needed when taken with other liver-affecting drugs. They share a common concern of potential interactions with medications that affect the liver. However, Aceclofenac is primarily concerned with interactions that increase bleeding risk, while Rabeprazole focuses on interactions affecting drug absorption.

Can I take combination of aceclofenac and rabeprazole if I am pregnant?

Aceclofenac is generally not recommended during pregnancy, especially in the third trimester, due to the risk of complications like premature closure of the ductus arteriosus, which is a vital blood vessel in the fetus. Rabeprazole's safety during pregnancy is not well-established, so it should only be used if the potential benefits justify the risks. Both medicines should be used with caution, and only under the guidance of a healthcare provider, who will weigh the benefits against potential risks to the mother and baby.

Can I take combination of Aceclofenac and Rabeprazole if I am pregnant?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, is generally not recommended during pregnancy, especially in the third trimester. This is because it can affect the baby's heart and blood flow. Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, is also not typically recommended during pregnancy unless absolutely necessary. This is due to limited data on its safety for the developing baby. Both Aceclofenac and Rabeprazole should be used with caution during pregnancy and only if the benefits outweigh the risks. They share the common attribute of being medications that require careful consideration and consultation with a healthcare provider before use during pregnancy. Each has unique uses: Aceclofenac for pain and inflammation, and Rabeprazole for acid-related issues. Always consult a doctor for advice tailored to individual health needs.

Can I take combination of aceclofenac and rabeprazole while breastfeeding?

Aceclofenac is generally not recommended during breastfeeding as it may pass into breast milk and affect the baby. Rabeprazole's safety during breastfeeding is not well-studied, so caution is advised. Both medicines should be used only if absolutely necessary and under the supervision of a healthcare provider. The decision to use these medications should consider the importance of the drug to the mother and the potential risks to the nursing infant. Alternatives with a better-established safety profile during breastfeeding may be considered.

Can I take combination of Aceclofenac and Rabeprazole while breastfeeding?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, is generally not recommended during breastfeeding. This is because it can pass into breast milk and may affect the baby. Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, is also not typically recommended for breastfeeding mothers. This is due to the lack of sufficient studies on its safety for nursing infants. Both medications share the common concern of potentially passing into breast milk and affecting the baby. However, they are used for different purposes: Aceclofenac for pain and inflammation, and Rabeprazole for reducing stomach acid. If a breastfeeding mother needs to take either medication, it is important to consult a healthcare provider to weigh the benefits and risks and to explore possible alternatives.

Who should avoid taking combination of aceclofenac and rabeprazole?

Aceclofenac should not be used by individuals with a history of gastrointestinal bleeding or severe heart failure, which is a condition where the heart can't pump blood effectively. Rabeprazole is contraindicated in people with known hypersensitivity to PPIs. Both medicines should be used cautiously in individuals with liver or kidney problems. It's important to avoid alcohol while taking aceclofenac, as it can increase the risk of stomach bleeding. Patients should inform their healthcare provider of their full medical history to ensure safe use.

Who should avoid taking combination of Aceclofenac and Rabeprazole?

Aceclofenac, which is a non-steroidal anti-inflammatory drug (NSAID), can cause stomach ulcers, bleeding, or kidney problems. It should be used with caution in people with heart disease, high blood pressure, or a history of stomach ulcers. Rabeprazole, which is a proton pump inhibitor (PPI), reduces stomach acid and can cause side effects like headaches or diarrhea. It should be used carefully in people with liver problems. Both drugs can interact with other medications, so it's important to inform your doctor about all medicines you are taking. They share a common risk of causing stomach issues, so they should be taken with food or as directed by a healthcare provider. Pregnant or breastfeeding women should consult their doctor before using these medications. Always follow the prescribed dosage and report any unusual symptoms to your healthcare provider.