Acalabrutinib
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Acalabrutinib
Summary
Acalabrutinib is used to treat blood cancers like mantle cell lymphoma and chronic lymphocytic leukemia.
Acalabrutinib works by inhibiting the BTK protein, which is involved in the growth and spread of cancer cells. By blocking this protein, it helps stop cancer cells from multiplying.
The usual dose for adults is 100 mg taken orally approximately every 12 hours. It can be taken with or without food.
Common side effects of Acalabrutinib include diarrhea, headache, and fatigue. Serious side effects can include infections, bleeding, and liver problems.
Acalabrutinib may harm an unborn baby and breastfeeding is not recommended. It can interact with certain medications and may cause dizziness or fatigue affecting your ability to drive. Regular monitoring by a doctor is essential.
Indications and Purpose
How does Acalabrutinib work?
Acalabrutinib works by inhibiting Bruton tyrosine kinase, a protein that plays a key role in the growth and survival of cancer cells. By blocking this protein, Acalabrutinib disrupts the signaling pathways that cancer cells use to grow and divide. This action helps slow down or stop the progression of certain blood cancers, making it an effective treatment option for these conditions.
Is Acalabrutinib effective?
Acalabrutinib is effective in treating certain types of blood cancers, such as mantle cell lymphoma and chronic lymphocytic leukemia. It works by blocking a protein that helps cancer cells grow. Clinical studies show Acalabrutinib can reduce cancer cell growth and improve survival rates. Your doctor will monitor your response to the medication to ensure it's working effectively for your condition.
What is Acalabrutinib?
Acalabrutinib is a medication used to treat certain types of blood cancers, such as mantle cell lymphoma and chronic lymphocytic leukemia. It belongs to a class of drugs called Bruton tyrosine kinase inhibitors, which work by blocking a protein that helps cancer cells grow. By inhibiting this protein, Acalabrutinib can slow down or stop the growth of cancer cells, helping to manage the disease.
Directions for Use
For how long do I take Acalabrutinib?
Acalabrutinib is usually a long-term medication for managing certain types of blood cancers. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Acalabrutinib treatment.
How do I dispose of Acalabrutinib?
To dispose of Acalabrutinib, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Acalabrutinib?
Acalabrutinib is usually taken as a capsule twice daily, about 12 hours apart. You should swallow the capsule whole with water, without crushing or chewing it. It's best to take Acalabrutinib on an empty stomach, either one hour before or two hours after a meal. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Acalabrutinib to start working?
Acalabrutinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and the specific condition being treated. Regular check-ups with your doctor will help monitor your progress and determine how well Acalabrutinib is working for you.
How should I store Acalabrutinib?
Store Acalabrutinib at room temperature, between 68°F to 77°F, in a tightly closed container. Protect it from moisture and light, which can damage the medication. Avoid storing it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Acalabrutinib out of children's reach to prevent accidental swallowing.
What is the usual dose of Acalabrutinib?
The usual starting dose of Acalabrutinib for adults is 100 mg taken twice daily. This dose is typically maintained unless your doctor advises adjustments based on your response or side effects. There is no maximum dose specified, but your doctor will monitor your treatment closely. Acalabrutinib is not typically used in children, and elderly patients may require careful monitoring. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can Acalabrutinib be taken safely while breastfeeding?
Acalabrutinib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. Animal studies suggest it could affect a baby's development. While specific harm to breastfed babies hasn't been reported, potential risks can't be ruled out. If you're taking Acalabrutinib and want to breastfeed, talk with your doctor about safer medication options.
Can Acalabrutinib be taken safely while pregnant?
Acalabrutinib is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks to the developing fetus. We don't have enough information about its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. They can help create a plan that protects both you and your baby.
Can I take Acalabrutinib with other prescription drugs?
Acalabrutinib can interact with certain medications, increasing the risk of side effects or reducing its effectiveness. Strong CYP3A inhibitors, like ketoconazole, can increase Acalabrutinib levels, leading to more side effects. Strong CYP3A inducers, like rifampin, can decrease its effectiveness. Always inform your doctor about all medications you're taking to avoid interactions. Your doctor can adjust your treatment to ensure safety and effectiveness.
Does Acalabrutinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Acalabrutinib include headache, diarrhea, and fatigue. These occur in a significant number of patients. Serious adverse effects can include bleeding, infections, and heart rhythm problems. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these are related to Acalabrutinib and advise on appropriate actions.
Does Acalabrutinib have any safety warnings?
Yes, Acalabrutinib has important safety warnings. It can increase the risk of bleeding, infections, and heart rhythm problems. These warnings are due to its effects on blood cells and the immune system. Not adhering to these warnings can lead to serious health issues. Always inform your doctor about any unusual symptoms, and follow their advice to minimize risks while taking Acalabrutinib.
Is Acalabrutinib addictive?
Acalabrutinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Acalabrutinib works by targeting specific proteins in cancer cells, which does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Acalabrutinib doesn't carry this risk.
Is Acalabrutinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Acalabrutinib, such as bleeding and infections. These risks are due to age-related changes in the body and the presence of other health conditions. Acalabrutinib can be used safely in the elderly with careful monitoring. Your doctor will assess your overall health and adjust your treatment as needed to minimize risks.
Is it safe to drink alcohol while taking Acalabrutinib?
It's best to avoid alcohol while taking Acalabrutinib. Alcohol can increase the risk of bleeding and liver problems, which are potential side effects of Acalabrutinib. Drinking alcohol may also worsen side effects like dizziness or low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like unusual bleeding or dizziness. Talk with your doctor about alcohol use while on Acalabrutinib.
Is it safe to exercise while taking Acalabrutinib?
You can exercise while taking Acalabrutinib, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, stay hydrated and avoid strenuous activities if you feel unwell. Watch for signs of dizziness or unusual fatigue during workouts. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns about your exercise routine.
Is it safe to stop Acalabrutinib?
Acalabrutinib is usually used for long-term treatment of chronic conditions like certain types of cancer. Stopping it suddenly can lead to a worsening of your condition. There are no specific withdrawal symptoms, but always talk with your doctor before stopping Acalabrutinib. They can guide you on how to safely discontinue or adjust your treatment to protect your health.
What are the most common side effects of Acalabrutinib?
Side effects are unwanted reactions to a medication. Common side effects of Acalabrutinib include headache, diarrhea, and fatigue. These occur in more than 10% of patients. If you experience new symptoms after starting Acalabrutinib, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication to ensure your treatment remains effective.
Who should avoid taking Acalabrutinib?
Acalabrutinib should not be used if you have a known allergy to it or its ingredients. This is an absolute contraindication due to the risk of severe allergic reactions. Use caution if you have a history of bleeding disorders or heart rhythm problems, as these are relative contraindications. Always discuss your medical history with your doctor to ensure Acalabrutinib is safe for you.
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