Acalabrutinib
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
NO
Acalabrutinib
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Click HereSummary
Acalabrutinib is used to treat blood cancers like mantle cell lymphoma and chronic lymphocytic leukemia.
Acalabrutinib works by inhibiting the BTK protein, which is involved in the growth and spread of cancer cells. By blocking this protein, it helps stop cancer cells from multiplying.
The usual dose for adults is 100 mg taken orally approximately every 12 hours. It can be taken with or without food.
Common side effects of Acalabrutinib include diarrhea, headache, and fatigue. Serious side effects can include infections, bleeding, and liver problems.
Acalabrutinib may harm an unborn baby and breastfeeding is not recommended. It can interact with certain medications and may cause dizziness or fatigue affecting your ability to drive. Regular monitoring by a doctor is essential.
Indications and Purpose
What is Acalabrutinib used for?
Acalabrutinib is indicated for the treatment of mantle cell lymphoma and chronic lymphocytic leukemia, both of which are types of blood cancers.
How does Acalabrutinib work?
Acalabrutinib inhibits the BTK protein, which is involved in the growth and spread of cancer cells. By blocking this protein, it helps stop cancer cells from multiplying.
Is Acalabrutinib effective?
Clinical trials have shown that Acalabrutinib is effective in treating mantle cell lymphoma and chronic lymphocytic leukemia by inhibiting the BTK protein, which helps stop cancer cell growth.
How does one know if Acalabrutinib is working?
The benefit of Acalabrutinib is evaluated through regular medical check-ups and lab tests to monitor the body's response and adjust treatment as needed.
Directions for Use
What is the usual dose of Acalabrutinib?
The usual dose for adults is 100 mg taken orally approximately every 12 hours. The safety and effectiveness of Acalabrutinib in children have not been established.
How do I take Acalabrutinib?
Take Acalabrutinib orally twice daily, about 12 hours apart, with or without food. Avoid grapefruit and grapefruit juice, as they can affect how the medicine works.
For how long do I take Acalabrutinib?
Acalabrutinib is typically taken until disease progression or unacceptable toxicity occurs. The exact duration varies based on individual response and medical advice.
How long does it take for Acalabrutinib to start working?
The time it takes for Acalabrutinib to start working can vary. Patients may begin to see effects within a few weeks, but it can take longer for full benefits. Regular monitoring by a doctor is essential.
How should I store Acalabrutinib?
Store Acalabrutinib at room temperature, away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children.
Warnings and Precautions
Who should avoid taking Acalabrutinib?
Acalabrutinib can cause serious infections, bleeding, and liver problems. It may also increase the risk of other cancers. Patients should be monitored for these conditions and discuss any concerns with their doctor.
Can I take Acalabrutinib with other prescription drugs?
Acalabrutinib interacts with strong CYP3A inhibitors and inducers, which can affect its effectiveness. Inform your doctor about all medications you are taking to avoid interactions.
Can I take Acalabrutinib with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Acalabrutinib be taken safely while pregnant?
Acalabrutinib may harm an unborn baby. Women should use effective contraception during treatment and for at least 1 week after the last dose. Discuss pregnancy plans with your doctor.
Can Acalabrutinib be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Acalabrutinib and for at least 2 weeks after the final dose due to potential harm to the infant.
Is Acalabrutinib safe for the elderly?
Elderly patients may experience more severe side effects. Regular monitoring and dose adjustments may be necessary. Discuss any concerns with your doctor to ensure safe use.
Is it safe to exercise while taking Acalabrutinib?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Acalabrutinib?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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