Abrocitinib
Atopic Dermatitis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Janus Kinase Inhibitor
Controlled Drug Substance
NO
Abrocitinib
Learn more about this medicine -
Click HereSummary
Abrocitinib is used to treat moderate to severe atopic dermatitis, or eczema, in adults and children aged 12 years and older. It's typically prescribed when other treatments haven't been effective or aren't suitable.
Abrocitinib works by inhibiting an enzyme called Janus kinase 1. This enzyme plays a key role in inflammation. By blocking it, Abrocitinib reduces the activity of the immune system, leading to decreased inflammation and relief from symptoms of atopic dermatitis.
The usual daily dose of Abrocitinib for adults and children aged 12 years and older is 100 mg once daily. If an adequate response isn't achieved, the dose may be increased to 200 mg once daily. It should be taken at the same time each day, with or without food.
Common side effects of Abrocitinib include nausea, headache, and dizziness. Serious adverse effects can include infections, blood clots, and cardiovascular events. If you experience any severe side effects, contact your doctor immediately.
Abrocitinib is contraindicated during pregnancy and breastfeeding, and in patients with active serious infections or severe hepatic impairment. It may increase the risk of serious infections, cardiovascular events, and certain cancers. It should be used with caution in elderly patients, especially those 65 years and older, due to increased risk of serious infections and cardiovascular events.
Indications and Purpose
What is Abrocitinib used for?
Abrocitinib is indicated for the treatment of moderate to severe atopic dermatitis, also known as eczema, in adults and children 12 years and older. It is prescribed when other treatments have not been effective or are not suitable for the patient.
How does Abrocitinib work?
Abrocitinib works by inhibiting Janus kinase 1 (JAK1), an enzyme that plays a key role in the inflammatory process. By blocking JAK1, Abrocitinib reduces the activity of the immune system, leading to decreased inflammation and relief from symptoms of atopic dermatitis.
Is Abrocitinib effective?
Clinical trials have shown that Abrocitinib is effective in treating moderate to severe atopic dermatitis in patients 12 years and older. It significantly improves skin condition and reduces itching compared to placebo. The medication works by inhibiting Janus kinase 1, which plays a role in the inflammatory process.
How does one know if Abrocitinib is working?
The benefit of Abrocitinib is evaluated through regular monitoring of the patient's response to treatment, including improvements in skin condition and reduction in itching. Doctors may also order lab tests to check for any adverse effects and adjust the treatment plan as necessary.
Directions for Use
What is the usual dose of Abrocitinib?
The usual daily dose of Abrocitinib for adults and children aged 12 years and older is 100 mg once daily. If an adequate response is not achieved, the dose may be increased to 200 mg once daily. Always follow your doctor's instructions regarding dosage.
How do I take Abrocitinib?
Abrocitinib should be taken once daily, with or without food, at the same time each day. There are no specific food restrictions while taking this medication. Always follow your doctor's instructions and consult them if you have any questions about your treatment.
For how long do I take Abrocitinib?
Abrocitinib is typically used for as long as it is effective and well-tolerated in managing eczema symptoms. The duration of use can vary based on individual response and medical advice. Always follow your doctor's guidance on how long to use this medication.
How long does it take for Abrocitinib to start working?
Abrocitinib may start to show improvement in symptoms within a few weeks of starting treatment. However, the full effect can take longer, and it is important to continue taking the medication as prescribed by your doctor. Regular follow-ups will help assess its effectiveness.
How should I store Abrocitinib?
Store Abrocitinib at room temperature between 68°F to 77°F (20°C to 25°C) in its original package. Keep it out of reach of children and away from excess heat and moisture. Ensure the container is tightly closed to maintain the medication's effectiveness.
Warnings and Precautions
Who should avoid taking Abrocitinib?
Abrocitinib may increase the risk of serious infections, cardiovascular events, and certain cancers. It is contraindicated in patients with active serious infections, severe hepatic impairment, and during pregnancy and breastfeeding. Patients should be monitored for infections and other adverse effects during treatment.
Can I take Abrocitinib with other prescription drugs?
Abrocitinib should not be used with strong CYP2C19 inhibitors, as they can increase the drug's exposure and risk of side effects. It should also be avoided with strong CYP2C19 or CYP2C9 inducers, which can reduce its effectiveness. Always inform your doctor about all medications you are taking.
Can I take Abrocitinib with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Abrocitinib be taken safely while pregnant?
Abrocitinib is contraindicated during pregnancy due to potential risks to the fetus. There is limited data on its use in pregnant women, but animal studies have shown reproductive toxicity. Women of childbearing potential should use effective contraception during treatment and consult their doctor if they become pregnant.
Can Abrocitinib be taken safely while breastfeeding?
Abrocitinib is contraindicated during breastfeeding as it is unknown if the drug passes into human milk. Due to potential serious adverse effects in infants, women are advised not to breastfeed while taking this medication. Consult your doctor for personalized advice.
Is Abrocitinib safe for the elderly?
For elderly patients, especially those 65 years and older, Abrocitinib should be used with caution due to an increased risk of serious infections, cardiovascular events, and malignancies. It should only be used if no suitable treatment alternatives are available. Regular monitoring and consultation with a healthcare provider are advised.
Is it safe to exercise while taking Abrocitinib?
Abrocitinib does not specifically limit the ability to exercise. However, if you experience side effects such as dizziness or tiredness, it may affect your ability to perform physical activities. Consult your doctor if you have concerns about exercising while taking this medication.
Is it safe to drink alcohol while taking Abrocitinib?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.