Abrocitinib
Atopic Dermatitis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Janus Kinase Inhibitor
Controlled Drug Substance
No
Abrocitinib
Summary
Abrocitinib is used to treat moderate to severe atopic dermatitis, or eczema, in adults and children aged 12 years and older. It's typically prescribed when other treatments haven't been effective or aren't suitable.
Abrocitinib works by inhibiting an enzyme called Janus kinase 1. This enzyme plays a key role in inflammation. By blocking it, Abrocitinib reduces the activity of the immune system, leading to decreased inflammation and relief from symptoms of atopic dermatitis.
The usual daily dose of Abrocitinib for adults and children aged 12 years and older is 100 mg once daily. If an adequate response isn't achieved, the dose may be increased to 200 mg once daily. It should be taken at the same time each day, with or without food.
Common side effects of Abrocitinib include nausea, headache, and dizziness. Serious adverse effects can include infections, blood clots, and cardiovascular events. If you experience any severe side effects, contact your doctor immediately.
Abrocitinib is contraindicated during pregnancy and breastfeeding, and in patients with active serious infections or severe hepatic impairment. It may increase the risk of serious infections, cardiovascular events, and certain cancers. It should be used with caution in elderly patients, especially those 65 years and older, due to increased risk of serious infections and cardiovascular events.
Indications and Purpose
How does Abrocitinib work?
Abrocitinib works by inhibiting Janus kinase enzymes, which are involved in the inflammatory process. Think of it like turning down the volume on a loudspeaker. By blocking these enzymes, Abrocitinib reduces inflammation and helps improve symptoms of atopic dermatitis, which is a skin condition causing itchy and inflamed skin. This makes it an effective treatment for managing this chronic condition.
Is Abrocitinib effective?
Abrocitinib is effective in treating moderate to severe atopic dermatitis, which is a chronic skin condition causing itchy and inflamed skin. Clinical studies show that Abrocitinib significantly reduces symptoms and improves skin condition in patients. It works by inhibiting certain enzymes in the body that contribute to inflammation. This makes it a valuable treatment option for managing atopic dermatitis.
What is Abrocitinib?
Abrocitinib is a medication used to treat moderate to severe atopic dermatitis, which is a chronic skin condition causing itchy and inflamed skin. It belongs to a class of drugs called Janus kinase inhibitors, which work by blocking certain enzymes in the body that contribute to inflammation. This helps reduce symptoms and improve skin condition. Abrocitinib is usually used when other treatments haven't been effective.
Directions for Use
For how long do I take Abrocitinib?
Abrocitinib is usually a long-term medication for managing chronic conditions like atopic dermatitis, which is a skin condition causing itchy and inflamed skin. You'll typically take Abrocitinib every day as a long-term treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Abrocitinib treatment.
How do I dispose of Abrocitinib?
Dispose of unused Abrocitinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Abrocitinib?
Take Abrocitinib as prescribed by your doctor, usually once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Abrocitinib to start working?
Abrocitinib begins working in your body shortly after you take it, but you may not notice all the benefits right away. Some improvement in symptoms like itching and skin appearance may be seen within a few days, but more significant changes typically take several weeks. How quickly the medication works can depend on your overall health and the severity of your condition. Take it exactly as prescribed for the best results.
How should I store Abrocitinib?
Store Abrocitinib at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store your medicine in humid places like bathrooms, where moisture could affect its effectiveness. Always store Abrocitinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Abrocitinib?
The usual starting dose of Abrocitinib for adults is 100 mg once daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 200 mg daily. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Abrocitinib be taken safely while breastfeeding?
The safety of Abrocitinib while breastfeeding is not well-established. It's unclear if the medication passes into human breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. They can help you make informed decisions to ensure the safety of your baby while managing your condition.
Can Abrocitinib be taken safely while pregnant?
The safety of Abrocitinib during pregnancy is not well-established. Animal studies suggest potential risks, but human data is limited. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Abrocitinib with other prescription drugs?
Abrocitinib should not be used with strong CYP2C19 inhibitors, as they can increase the drug's exposure and risk of side effects. It should also be avoided with strong CYP2C19 or CYP2C9 inducers, which can reduce its effectiveness. Always inform your doctor about all medications you are taking.
Does Abrocitinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Abrocitinib include nausea, headache, and upper respiratory infections. These effects vary in frequency and severity. Serious side effects can include infections and blood clots, which require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Abrocitinib to ensure safe and effective treatment.
Does Abrocitinib have any safety warnings?
Yes, Abrocitinib has important safety warnings. It can increase the risk of serious infections and blood clots. If you experience symptoms like fever, chills, or unusual bleeding, seek medical help. Abrocitinib may also affect your blood cell counts, so regular monitoring is necessary. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any new symptoms.
Is Abrocitinib addictive?
Abrocitinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Abrocitinib works by affecting your immune system to help manage your condition. It doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Abrocitinib doesn't carry this risk while managing your health condition.
Is Abrocitinib safe for the elderly?
For elderly patients, especially those 65 years and older, Abrocitinib should be used with caution due to an increased risk of serious infections, cardiovascular events, and malignancies. It should only be used if no suitable treatment alternatives are available. Regular monitoring and consultation with a healthcare provider are advised.
Is it safe to drink alcohol while taking Abrocitinib?
It's best to avoid alcohol while taking Abrocitinib. Alcohol can increase the risk of side effects like dizziness and may interfere with the medication's effectiveness. If you choose to drink occasionally, limit your alcohol intake and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking Abrocitinib to get personalized advice.
Is it safe to exercise while taking Abrocitinib?
You can exercise while taking Abrocitinib, but be mindful of potential side effects like dizziness. This medication can cause dehydration, so drink plenty of water before, during, and after physical activity. If you feel dizzy or unusually fatigued, slow down or stop exercising and rest. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns.
Is it safe to stop Abrocitinib?
Stopping Abrocitinib suddenly can cause your condition to worsen. It's used for long-term management of chronic conditions. If you stop taking it without medical advice, your symptoms may return or worsen. Always talk with your doctor before stopping Abrocitinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Abrocitinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Abrocitinib include nausea, headache, and upper respiratory infections. These effects vary from person to person. If you notice new symptoms after starting Abrocitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Abrocitinib?
Do not take Abrocitinib if you're allergic to it or its ingredients. It's contraindicated in patients with severe liver impairment. Caution is needed for those with a history of blood clots or serious infections. Always consult your doctor about these concerns. They will assess if the benefits of Abrocitinib outweigh the risks in your specific case.
