Abiraterone acetate
Prostatic Neoplasms, Castration-Resistant
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Possible
Pharmaceutical Class
Cytochrome P450 17A1 Inhibitor
Controlled Drug Substance
NO
Abiraterone acetate
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Click HereSummary
Abiraterone is used to treat prostate cancer that has spread to other parts of the body. It is used for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC).
Abiraterone works by blocking the production of androgens, such as testosterone, which fuel cancer growth. It blocks the CYP17 enzyme needed to produce these hormones, thereby slowing prostate cancer growth.
The usual dose for adults is 1000 mg, taken once daily on an empty stomach. It is usually prescribed with 5 mg of prednisone twice daily to help prevent side effects. Do not crush or chew the tablets, swallow them whole with water.
Common side effects include high blood pressure, liver problems, low potassium, fluid retention, and fatigue. Some people may also experience nausea, vomiting, diarrhea, and weight gain. It can also cause mood changes and sleep disturbances.
Abiraterone is not for use in women, especially pregnant women as it can harm the unborn baby. People with severe liver disease, uncontrolled high blood pressure or heart problems should avoid it. It can interact with certain medications and supplements, so always consult your doctor before taking any new medication or supplement.
Indications and Purpose
What is Abiraterone acetate used for?
It is used to treat metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC). It is given when the cancer has spread beyond the prostate and is no longer responding to standard hormone therapy.
How does Abiraterone acetate work?
It blocks the CYP17 enzyme, which is needed to produce testosterone and other androgens. By lowering these hormones, Abiraterone slows prostate cancer growth.
Is Abiraterone acetate effective?
Yes, studies show Abiraterone significantly prolongs survival in prostate cancer patients, especially when combined with prednisone. It reduces tumor growth, delays the need for chemotherapy, and improves quality of life.
How does one know if Abiraterone acetate is working?
Your doctor will monitor PSA (prostate-specific antigen) levels, imaging scans, and symptoms like bone pain. A decline in PSA and reduced tumor size indicate the treatment is working.
Directions for Use
What is the usual dose of Abiraterone acetate?
The usual dose for adults is 1,000 mg (four 250 mg tablets) once daily, taken on an empty stomach. It is usually prescribed with 5 mg of prednisone twice daily to help prevent side effects like high blood pressure and liver problems. Dose adjustments may be needed for people with liver issues. Children should not take Abiraterone.
How do I take Abiraterone acetate?
Take on an empty stomach, at least one hour before or two hours after a meal. Swallow the tablets whole with water. Do not crush or chew them. Always take Abiraterone as prescribed, along with prednisone, to lower the risk of side effects. If you miss a dose, take it as soon as possible, but do not double the dose.
For how long do I take Abiraterone acetate?
Abiraterone is taken as long as it remains effective in controlling cancer and the side effects are manageable. Your doctor will monitor your response to treatment with regular blood tests and scans. If the cancer progresses despite treatment, your doctor may adjust your therapy.
How long does it take for Abiraterone acetate to start working?
It starts lowering androgen levels within a few hours, but noticeable effects on cancer progression may take several weeks or months. Your doctor will check PSA levels and imaging tests to monitor progress.
How should I store Abiraterone acetate?
Store at room temperature (20–25°C) in a dry place, away from heat and moisture. Keep out of reach of children.
Warnings and Precautions
Who should avoid taking Abiraterone acetate?
People with severe liver disease, uncontrolled high blood pressure, or heart problems should avoid it. Pregnant women should not handle the tablets, as the drug can cause harm to an unborn baby.
Can I take Abiraterone acetate with other prescription drugs?
Abiraterone interacts with rifampin, phenytoin, carbamazepine, and ketoconazole, which can alter its effectiveness. Tell your doctor about all medications you are taking.
Can I take Abiraterone acetate with vitamins or supplements?
Avoid potassium supplements and herbal products like St. John’s Wort, which may reduce its effectiveness. Always consult your doctor before taking any supplements.
Can Abiraterone acetate be taken safely while pregnant?
No, Abiraterone is not for use in women, especially pregnant women, as it can harm the unborn baby. Men should use effective contraception during treatment.
Can Abiraterone acetate be taken safely while breastfeeding?
It is not for use in women, including those who are breastfeeding. There is no data on its safety in lactation.
Is Abiraterone acetate safe for the elderly?
Yes, it is commonly used in elderly patients, but they should be monitored closely for heart issues, liver problems, and high blood pressure.
Is it safe to exercise while taking Abiraterone acetate?
Yes, light to moderate exercise is generally safe and can help reduce fatigue and weight gain. Avoid strenuous activity if you feel weak or dizzy.
Is it safe to drink alcohol while taking Abiraterone acetate?
Alcohol can worsen liver problems and high blood pressure, so it’s best to limit or avoid alcohol while on Abiraterone.
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