Abiraterone acetate
Prostatic Neoplasms, Castration-Resistant
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Possible
Pharmaceutical Class
Cytochrome P450 17A1 Inhibitor
Controlled Drug Substance
No
Abiraterone acetate
Summary
Abiraterone is used to treat prostate cancer that has spread to other parts of the body. It is used for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC).
Abiraterone works by blocking the production of androgens, such as testosterone, which fuel cancer growth. It blocks the CYP17 enzyme needed to produce these hormones, thereby slowing prostate cancer growth.
The usual dose for adults is 1000 mg, taken once daily on an empty stomach. It is usually prescribed with 5 mg of prednisone twice daily to help prevent side effects. Do not crush or chew the tablets, swallow them whole with water.
Common side effects include high blood pressure, liver problems, low potassium, fluid retention, and fatigue. Some people may also experience nausea, vomiting, diarrhea, and weight gain. It can also cause mood changes and sleep disturbances.
Abiraterone is not for use in women, especially pregnant women as it can harm the unborn baby. People with severe liver disease, uncontrolled high blood pressure or heart problems should avoid it. It can interact with certain medications and supplements, so always consult your doctor before taking any new medication or supplement.
Indications and Purpose
How does Abiraterone acetate work?
Abiraterone acetate works by blocking the production of androgens, which are male hormones that can promote prostate cancer growth. It inhibits an enzyme called CYP17, which is involved in androgen production. Think of it like turning off a faucet to stop water flow. By reducing androgen levels, Abiraterone acetate helps slow the progression of prostate cancer. This medication is effective in treating advanced prostate cancer, especially when used in combination with other treatments like prednisone. Regular monitoring by your healthcare provider ensures the medication is working as intended.
Is Abiraterone acetate effective?
Yes, Abiraterone acetate is effective for treating prostate cancer. It works by reducing the production of androgens, which are male hormones that can promote cancer growth. Clinical studies show that Abiraterone acetate can improve survival rates and delay disease progression in men with advanced prostate cancer. It is often used in combination with other treatments, such as prednisone, to enhance its effectiveness. Regular monitoring by your healthcare provider ensures that the medication is working as intended and allows for any necessary adjustments to your treatment plan.
What is Abiraterone acetate?
Abiraterone acetate is a medication used to treat prostate cancer. It belongs to a class of drugs called androgen biosynthesis inhibitors, which work by reducing the production of androgens, which are male hormones that can promote cancer growth. By lowering androgen levels, Abiraterone acetate helps slow the progression of prostate cancer. It's often used in combination with other treatments, such as prednisone, to enhance its effectiveness. This medication is specifically indicated for men with advanced prostate cancer that has spread to other parts of the body.
Directions for Use
For how long do I take Abiraterone acetate?
Abiraterone acetate is usually a long-term medication for managing prostate cancer. You'll typically take it every day as part of your ongoing treatment unless your doctor suggests otherwise. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Abiraterone acetate treatment. They will guide you on the best course of action for your health needs.
How do I dispose of Abiraterone acetate?
To dispose of Abiraterone acetate, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion by children or pets.
How do I take Abiraterone acetate?
Take Abiraterone acetate on an empty stomach, either one hour before or two hours after a meal. It's usually taken once daily. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid eating food around the time you take this medication, as it can affect how well the medicine works. Always follow your doctor's specific instructions for taking this medication.
How long does it take for Abiraterone acetate to start working?
Abiraterone acetate begins working in your body shortly after you take it, but you may not notice all the benefits right away. It can take several weeks to see significant improvements in prostate cancer symptoms. Your doctor will monitor your progress through regular blood tests, which measure prostate-specific antigen (PSA) levels. A decrease in PSA levels indicates the medication is working. How quickly the medication works can depend on your overall health and how advanced your cancer is. Take it exactly as prescribed for the best results.
How should I store Abiraterone acetate?
Store Abiraterone acetate at room temperature, between 68°F to 77°F. Keep it in a tightly closed container to protect it from moisture and light, which can damage the medication. Avoid storing it in humid places like bathrooms, where moisture in the air could affect its effectiveness. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Abiraterone acetate out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Abiraterone acetate?
The usual starting dose of Abiraterone acetate for adults is 1,000 mg taken once daily. It's important to take it on an empty stomach, either one hour before or two hours after a meal. Dose adjustments may be necessary based on your response to the medication and any side effects. The maximum recommended dose is typically 1,000 mg per day. There are no specific dosing instructions for children, as this medication is not usually prescribed for them. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Abiraterone acetate be taken safely while breastfeeding?
No, Abiraterone acetate is not safe to use while breastfeeding. There is limited information on whether this medication passes into breast milk, but it could potentially harm a nursing infant. Abiraterone acetate is used to treat prostate cancer, which is not a condition that affects breastfeeding women. If you are breastfeeding or planning to breastfeed, talk with your doctor about safer treatment options. Your healthcare provider can help you find a medication that allows you to nurse your baby safely.
Can Abiraterone acetate be taken safely while pregnant?
No, Abiraterone acetate is not safe to use during pregnancy. It can harm the unborn baby. This medication is used to treat prostate cancer, which is not a condition that affects pregnant women. If you are pregnant or planning to become pregnant, talk with your doctor about safer treatment options. It's important to use effective birth control while taking this medication to prevent pregnancy. Always consult your healthcare provider for guidance on medication use during pregnancy to ensure the safety of both mother and baby.
Can I take Abiraterone acetate with other prescription drugs?
Abiraterone acetate has some concerning drug interactions. It can interact with medications like ketoconazole, which is an antifungal, and rifampin, which is an antibiotic, potentially reducing its effectiveness. It may also increase the effects of blood thinners like warfarin, raising the risk of bleeding. Always inform your doctor about all medications you're taking to avoid harmful interactions. Your doctor can adjust your treatment plan to ensure it's safe and effective. Regular monitoring and communication with your healthcare provider are key to managing drug interactions.
Does Abiraterone acetate have adverse effects?
Yes, Abiraterone acetate can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include fatigue, joint pain, and hot flashes. These occur in more than 10% of users. Serious side effects can include high blood pressure and liver problems. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to the medication and adjust your treatment if necessary. Monitoring and communication with your healthcare provider are key to managing adverse effects.
Does Abiraterone acetate have any safety warnings?
Yes, Abiraterone acetate has important safety warnings. It can cause high blood pressure, low potassium levels, and fluid retention, which is when your body holds onto too much water. These issues can lead to serious heart problems. Regular monitoring of blood pressure and potassium levels is necessary. Not following these safety warnings can result in severe health complications. Always adhere to your doctor's advice and report any unusual symptoms immediately. This ensures your treatment is safe and effective.
Is Abiraterone acetate addictive?
No, Abiraterone acetate is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by affecting hormone levels in your body, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings or feel compelled to take more than prescribed. If you have concerns about medication dependence, rest assured that Abiraterone acetate doesn't carry this risk. Always follow your doctor's instructions for safe and effective use.
Is Abiraterone acetate safe for the elderly?
Yes, Abiraterone acetate can be used by the elderly, but with caution. Older adults are more vulnerable to side effects like high blood pressure and liver problems. Regular monitoring of blood pressure and liver function is important. The elderly may also experience more fatigue and joint pain. It's crucial to follow your doctor's instructions and report any unusual symptoms. Your healthcare provider will adjust your treatment as needed to ensure it's safe and effective for you. Always discuss any concerns with your doctor.
Is it safe to drink alcohol while taking Abiraterone acetate?
It's best to avoid alcohol while taking Abiraterone acetate. Alcohol can increase the risk of liver damage, which is a potential side effect of this medication. Drinking alcohol may also worsen other side effects like dizziness or fatigue. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or unusual tiredness. These symptoms could indicate liver problems and require immediate medical attention. Talk with your doctor about alcohol use while taking Abiraterone acetate for personalized advice.
Is it safe to exercise while taking Abiraterone acetate?
Yes, you can exercise while taking Abiraterone acetate, but be mindful of your body's response. This medication can cause fatigue and joint pain, which might affect your exercise capacity. If you feel unusually tired or experience joint discomfort during physical activity, slow down or stop and rest. To exercise safely, stay hydrated and avoid strenuous activities if you're feeling unwell. Most people can maintain their regular exercise routine while taking Abiraterone acetate, but consult your doctor if you have concerns about your specific situation.
Is it safe to stop Abiraterone acetate?
No, it's not safe to stop Abiraterone acetate suddenly without consulting your doctor. This medication is usually used for long-term treatment of prostate cancer. Stopping it abruptly can cause your condition to worsen. There are no specific withdrawal symptoms, but your cancer may progress if you stop treatment. Always talk with your doctor before making any changes to your medication. They can guide you on how to safely adjust or stop your treatment if necessary, ensuring your health is protected.
What are the most common side effects of Abiraterone acetate?
Side effects are unwanted reactions that can occur with medication use. Common side effects of Abiraterone acetate include fatigue, joint pain, and hot flashes. These affect more than 10% of people taking the medication. It's important to note that side effects can vary from person to person. If you experience new symptoms after starting Abiraterone acetate, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related and suggest ways to manage them.
Who should avoid taking Abiraterone acetate?
Abiraterone acetate has important contraindications. It should not be used by people with severe liver impairment, which is when the liver cannot function properly. This medication can worsen liver problems. Pregnant women should also avoid it, as it can harm the unborn baby. Use caution if you have a history of heart problems, as Abiraterone acetate can increase blood pressure. Always consult your doctor about your medical history before starting this medication. They can determine if it's safe for you and discuss any potential risks.
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