Abemaciclib
Breast Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Abemaciclib
Summary
Abemaciclib is used to treat hormone receptor-positive, HER2-negative breast cancer. It can be used in both early and advanced stages of the disease. It's also used for advanced breast cancer that has progressed after prior treatments.
Abemaciclib works by inhibiting proteins called cyclin-dependent kinases 4 and 6. These proteins are crucial for cell division. By blocking these proteins, Abemaciclib slows or stops the growth of cancer cells.
Abemaciclib is typically prescribed for adults. The recommended dose is 150 mg taken orally twice daily. It can be used in combination with other therapies.
Common side effects of Abemaciclib include diarrhea, nausea, fatigue, and neutropenia. Serious adverse effects can include severe diarrhea, hepatotoxicity, and venous thromboembolism.
Abemaciclib can cause severe diarrhea, neutropenia, hepatotoxicity, and venous thromboembolism. It's contraindicated in patients with hypersensitivity to the drug or its components. It's also advised to avoid strong CYP3A4 inhibitors and inducers.
Indications and Purpose
How does Abemaciclib work?
Abemaciclib works by inhibiting proteins called CDK4 and CDK6, which are involved in cell division. By blocking these proteins, Abemaciclib slows down the growth of cancer cells. Think of it like putting brakes on a car to slow it down. This helps control the progression of certain types of breast cancer.
Is Abemaciclib effective?
Abemaciclib is effective in treating certain types of breast cancer. It works by inhibiting proteins that promote cancer cell growth. Clinical studies show it can slow disease progression and improve survival rates. Your doctor will monitor your response to the medication through regular check-ups and tests to ensure it's working effectively for you.
What is Abemaciclib?
Abemaciclib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called CDK4/6 inhibitors, which work by blocking proteins that promote cancer cell growth. This helps slow the progression of cancer. Abemaciclib is often used in combination with other therapies to enhance its effectiveness.
Directions for Use
For how long do I take Abemaciclib?
Abemaciclib is usually a long-term medication for managing certain types of breast cancer. You'll typically take it every day as part of your cancer treatment plan. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Abemaciclib?
Bring unused Abemaciclib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Abemaciclib?
Take Abemaciclib exactly as your doctor prescribes. It's usually taken twice daily, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Abemaciclib to start working?
Abemaciclib starts working in your body shortly after you take it, but you may not notice all the benefits right away. It can take several weeks to see significant changes in your cancer's progression. How quickly it works can depend on your overall health and how your body responds to the medication.
How should I store Abemaciclib?
Store Abemaciclib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep it out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Abemaciclib?
The usual starting dose of Abemaciclib for adults is 150 mg taken twice daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 200 mg twice daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Abemaciclib be taken safely while breastfeeding?
Abemaciclib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. If you're taking Abemaciclib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Abemaciclib be taken safely while pregnant?
Abemaciclib is not recommended during pregnancy. It can harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Abemaciclib with other prescription drugs?
Abemaciclib can interact with certain medications, increasing the risk of side effects. Strong CYP3A inhibitors, like ketoconazole, can increase Abemaciclib levels in your body. This may lead to more side effects. Always inform your doctor about all medications you're taking to avoid potential interactions and ensure safe treatment.
Does Abemaciclib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Abemaciclib include diarrhea, nausea, and fatigue. Serious effects can include liver problems and low white blood cell counts. If you experience severe side effects, contact your doctor immediately. Always inform your doctor about any new or worsening symptoms while taking Abemaciclib.
Does Abemaciclib have any safety warnings?
Yes, Abemaciclib has important safety warnings. It can cause diarrhea, which may lead to dehydration. Monitor for signs of infection, as it can lower white blood cell counts. Liver function should be checked regularly, as it can cause liver problems. If you experience severe side effects, contact your doctor immediately. Always follow your doctor's advice and report any new symptoms.
Is Abemaciclib addictive?
Abemaciclib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by inhibiting certain proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Abemaciclib doesn't carry this risk.
Is Abemaciclib safe for the elderly?
No overall differences in safety or effectiveness of Abemaciclib were observed between elderly patients and younger patients. However, elderly patients may be more susceptible to certain side effects, such as neutropenia and diarrhea. It is important for elderly patients to be closely monitored by their healthcare provider during treatment.
Is it safe to drink alcohol while taking Abemaciclib?
It's best to avoid alcohol while taking Abemaciclib. Alcohol can increase the risk of liver problems, which is a concern with this medication. If you do choose to drink occasionally, limit how much alcohol you consume. Talk with your doctor about alcohol use while taking Abemaciclib to get personalized advice.
Is it safe to exercise while taking Abemaciclib?
You can exercise while taking Abemaciclib, but be cautious. This medication can cause fatigue and diarrhea, which might affect your exercise capacity. To exercise safely, listen to your body and rest if you feel tired. Stay hydrated and avoid strenuous activities if you experience side effects. Consult your doctor if you have concerns.
Is it safe to stop Abemaciclib?
Stopping Abemaciclib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Abemaciclib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Abemaciclib?
Side effects are unwanted reactions to a medication. Common side effects of Abemaciclib include diarrhea, nausea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Abemaciclib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Abemaciclib?
Don't take Abemaciclib if you're allergic to it or its ingredients. It's not recommended for people with severe liver problems. Caution is needed if you have a history of blood clots or are pregnant. Always consult your doctor about these concerns before starting Abemaciclib to ensure it's safe for you.
