To avoid an upset stomach it is recommended to take Xtrapred Drop with food Swallow the drop whole with water at the same time every day as prescribed by your doctor It is possible that the dose and frequency may be adjusted by your doctor based on the effectiveness of the medication It is important to take this medicine regularly in order to receive maximum benefits even if you feel well Common side effects of Xtrapred Drop include a reduction in bone density weight gain mood changes upset stomach and behavioral changes If you experience any of these side effects and they are bothersome or do not subside it is advisable to discuss them with your doctor Taking Xtrapred Drop may also weaken your immune system making it more difficult for your body to fight off infections Notify your doctor if you experience any signs of infection such as a fever or sore throat Inform your doctor about any medical conditions you have especially poor blood circulation diabetes and immune system problems It is also important to disclose any other medications you are currently taking particularly steroids