Glimepiride stimulates the release of insulin from the pancreas, while metformin reduces the amount of glucose produced by the liver and helps the body use insulin more effectively. Pioglitazone helps the body use insulin more effectively and also reduces glucose production by the liver.

["Take the medication as prescribed by your doctor. Do not break, chew, or crush it. It should be taken with food."]

--Hypoglycemia, gastrointestinal disturbances, taste disturbances, nausea, diarrhoea, allergic skin reactions, photosensitivity, weight gain, upper respiratory tract infection, headache, dizziness, fracture, visual disturbance, anaemia, hepatic dysfunction, jaundice, thrombocytopenia, leucopenia, agranulocytosis, haemolytic anaemia, aplastic anaemia, pancytopenia, bone marrow depression, fluid retention, oedema, cardiac failure, macular oedema, bladder cancer, lactic acidosis.