prethromb (PRASUGREL)
Introduction to Prethromb
Prethromb is a medication primarily used to prevent blood clots in patients with acute coronary syndrome. It is especially beneficial for those undergoing procedures like sten... See More
What is Prethromb?
Prethromb helps reduce the risk of heart or blood vessel problems like heart attacks, strokes, and blood clots in stents. It works by preventing platelets from clumping together and forming clots.
What is the usual dose of Prethromb?
This medication is taken by mouth. The first dose is 60 mg, and then you take 10 mg once a day after that. There is no information about how much children should take.
How do I take Prethromb?
Prethromb can be taken with or without food. There are no specific food restrictions while taking this medication. However, it is important to swallow the tablet whole, without crushing or chewing it. If you have difficulty swallowing pills, consult your doctor for alternative options. Always take the medication as prescribed and follow the doctor's instructions.
For how long do I take Prethromb?
The typical duration of Prethromb treatment is generally 6 to 12 months for patients with acute coronary syndromes undergoing percutaneous coronary intervention. Some studies indicate that treatment may extend up to 14.5 months or longer, depending on individual patient circumstances. It's essential for patients to consult their healthcare provider to determine the appropriate duration based on their specific health needs and risks.
What is Prethromb used for?
Prethromb is primarily indicated for the prevention of blood clots in patients with acute coronary syndrome (ACS), specifically those undergoing percutaneous coronary intervention (PCI), including stent placement. It is used in combination with aspirin to reduce the risk of thrombotic events like heart attacks, strokes, and other cardiovascular complications in these patients.
How long does it take for Prethromb to start working?
Prethromb typically starts working within 30 minutes to 1 hour after ingestion, with its full effects usually seen within a few hours. This rapid onset helps in reducing the risk of blood clot formation, particularly in patients undergoing procedures like angioplasty or those with acute coronary syndrome. However, its maximum effect may take a few days of regular use.
Is Prethromb effective?
Prethromb has been proven effective through clinical studies, particularly in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The TRITON-TIMI 38 trial showed that Prethromb significantly reduced the risk of cardiovascular events (like heart attacks, stent thrombosis, and death from cardiovascular causes) compared to clopidogrel. Its faster and more potent platelet inhibition contributed to these outcomes, particularly in high-risk patients.
How does one know if Prethromb is working?
The benefit of Prethromb is primarily evaluated through clinical trials and patient outcomes. Key metrics include the reduction in the risk of major cardiovascular events such as heart attack, stroke, and death from cardiovascular causes, particularly in patients with acute coronary syndrome (ACS). Additionally, platelet inhibition is monitored to assess the drug's effectiveness in preventing thrombus formation, often measured by platelet function tests. Regular follow-up visits help track patient progress and any side effects.
How does Prethromb work?
Prethromb is an antiplatelet medication that works by inhibiting platelet aggregation. It irreversibly blocks the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. This inhibition reduces platelet activation and aggregation, thereby preventing the formation of blood clots. By reducing clot formation, Prethromb helps to lower the risk of heart attacks, strokes, and other thrombotic events in patients with acute coronary syndrome.
Who should avoid taking Prethromb?
Prethromb is contraindicated in individuals with active bleeding disorders, a history of intracranial hemorrhage, or severe hepatic impairment. It should be used with caution in people with a history of gastrointestinal bleeding, stroke, or those undergoing surgery. Warnings include an increased risk of bleeding, including fatal bleeding, and the need for careful monitoring during treatment, particularly in elderly patients and those with low body weight.
Can I take Prethromb with vitamins or supplements?
Prethromb can interact with certain vitamins and supplements, particularly those that affect blood clotting. Vitamin E, fish oil, and other omega-3 fatty acids, which have blood-thinning effects, may increase the risk of bleeding when used with Prethromb. It's important to inform a healthcare provider about any supplements being taken to adjust treatment appropriately and minimize risks.
Can I take Prethromb with other prescription drugs?
Prethromb can interact with medications that increase bleeding risk, including anticoagulants (warfarin, heparin), antiplatelet drugs (aspirin, clopidogrel), and NSAIDs, which may heighten bleeding risks. Proton pump inhibitors (e.g., omeprazole) may reduce Prethromb’s effectiveness. Always consult a healthcare provider before using Prethromb with other drugs to avoid harmful interactions.
Can Prethromb be taken safely while pregnant?
Prethromb is classified as Pregnancy Category B by the FDA, meaning that it is not expected to harm an unborn baby based on animal studies. However, there are no well-controlled studies in pregnant women, so it should be used only if clearly needed. It is recommended to consult a healthcare provider before using Prethromb during pregnancy.
Can Prethromb be taken safely while breastfeeding?
Prethromb is not recommended for use during breastfeeding, as it is not known whether it passes into breast milk. Given the potential for serious side effects, such as bleeding, it is advised to consult a healthcare provider before using Prethromb while breastfeeding. Alternative treatments may be considered to avoid potential risks to the infant.
Is Prethromb safe for the elderly?
Prethromb is a medication used to prevent blood clots. It's usually not given to people who are 75 or older because it can make them more likely to bleed, sometimes seriously or even fatally. This is more common with Prethromb than with a similar medication called clopidogrel. However, people who are 75 or older may still be given Prethromb if they have certain conditions, like diabetes or a previous heart attack. In these cases, the benefits of the medication may outweigh the risks. It's important to note that the risk of bleeding increases with age, but the risk of bleeding with Prethromb compared to clopidogrel is about the same for people of all ages.
How should I store Prethromb?
Store the Prethromb at normal room temperature, between 59°F to 86°F (15°C to 30°C). Keep the Prethromb in their original container, with the lid tightly closed. The container includes a drying agent to absorb moisture, so don't remove it.
Does Prethromb make people tired or drowsy?
Prethromb doesn’t usually cause tiredness or drowsiness. If you feel unusually tired, talk to your doctor.
Does Prethromb cause stomach upset?
Some people may experience nausea or stomach discomfort. Taking it with food might help. Contact your doctor if it continues.
Does Prethromb affect sleep?
It typically doesn’t affect sleep. Let your doctor know if you have trouble sleeping.
Does Prethromb make it hard to think or concentrate?
This medicine usually doesn’t affect your thinking. If you notice confusion or trouble focusing, consult your doctor.
Does Prethromb affect mood?
Mood changes are uncommon. If you feel unusually emotional or notice mood swings, inform your doctor.
Does Prethromb interfere with sexual function?
There’s no evidence suggesting Prethromb impacts sexual function.
Does Prethromb affect appetite?
Prethromb rarely affects appetite. Let your doctor know if you notice any significant changes in your eating habits.
Does Prethromb cause weight gain?
This medicine is not known to cause weight gain.
Does Prethromb cause headaches?
Headaches can sometimes happen. If they persist or bother you, talk to your doctor.
Does Prethromb limit driving?
Prethromb doesn’t directly affect driving. However, avoid driving if you feel dizzy or unwell.
Is it safe to drink alcohol while taking Prethromb?
Alcohol increases the risk of bleeding or stomach problems, so it’s best to avoid it with this medicine.
Is it safe to drink coffee or tea while taking Prethromb?
You can drink coffee or tea, but don’t overdo it if you notice stomach upset.
Is it safe to exercise while taking Prethromb?
Exercise is fine, but avoid high-risk activities since this medicine increases bleeding risks. Follow your doctor’s guidance.
What are Prethromb possible harms and risks?
The most common side effects of Prethromb include bleeding, bruising, and nosebleeds. Other less frequent side effects may include dizziness, headache, rash, or gastrointestinal symptoms such as nausea. Significant adverse effects include serious bleeding events (such as intracranial hemorrhage or gastrointestinal bleeding), severe allergic reactions, and thrombocytopenia (low platelet count). These can increase the risk of major bleeding and require immediate medical attention.
Available in 2 variations
Prethromb 5mg Tablet
Prethromb 5mg Tablet
Prasugrel (5mg)
strip of 10 tablets
Prethromb 10mg Tablet
Prethromb 10mg Tablet
Prasugrel (10mg)
strip of 10 tablets
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