pletoz (CILOSTAZOL)

What is Pletoz?

Pletoz tablets are a medication prescribed to help people with intermittent claudication, a condition that causes pain in the legs when walking. It works by preventing a particular protein from working, which helps increase walking distance. Some common side effects of Pletoz tablets include headache, diarrhea, upset stomach, rapid heartbeat, dizziness, sore throat, infection, swelling in the hands or feet, runny nose, indigestion, and abdominal pain.

How do I take Pletoz?

Take your Pletoz tablets exactly as your doctor tells you. Your doctor will tell you how much to take and when. Your doctor may change your dose if needed. Take your tablets 30 minutes before you eat or 2 hours after you eat.

For how long do I take Pletoz?

The typical duration of use for Pletoz depends on the condition being treated:

• Intermittent Claudication: Patients may start experiencing improvement in symptoms (e.g., increased walking distance) within 2 to 4 weeks. However, a trial period of up to 12 weeks is recommended to assess the full therapeutic effect. If no improvement is seen after 3 months, discontinuation of the medication is advised​.

For long-term use, patients should continue taking Pletoz as directed by their healthcare provider while monitoring for efficacy and side effects.

What is Pletoz used for?

Pletoz is a medication that helps people with intermittent claudication walk farther without pain. Intermittent claudication is a condition that causes pain in the legs when walking due to poor blood flow. Pletoz works by improving blood flow to the legs, which reduces pain and allows people to walk farther.

How long does it take for Pletoz to start working?

You may notice improvement in your symptoms within 2 weeks, but it could take up to 12 weeks to see the full benefit.

Is Pletoz effective?

Pletoz is a medicine that helps people with intermittent claudication, a condition that causes pain in the legs when walking. In studies, people who took Pletoz either 100 mg or 50 mg twice a day walked further and faster than people who took a placebo (sugar pill). The improvement was noticeable within the first few weeks of taking the medicine. In some studies, people who took Pletoz 100 mg twice a day increased their walking distance by up to 100% compared to before they started taking the medicine.

How does one know if Pletoz is working?

You’ll know Pletoz is working if you experience improved walking distance and reduced leg pain associated with intermittent claudication. It may take 2 to 4 weeks to notice initial improvements, with maximum benefits typically seen after 12 weeks of consistent use. Regular follow-ups with your doctor can help assess progress and make adjustments if needed.

How does Pletoz work?

Pletoz is a medication that works by increasing the level of a chemical called cAMP in the body. cAMP helps to prevent blood clots from forming by stopping platelets from sticking together. It also helps to relax blood vessels, which can improve blood flow. Pletoz is used to treat people who have problems with blood circulation, such as claudication (leg pain caused by poor blood flow) and Raynaud's disease (a condition that causes the fingers and toes to turn white and cold).

Who should avoid taking Pletoz?

Pletoz can cause serious health problems, such as heart issues and allergic reactions. Do not take it if you have heart failure. Call your doctor or go to the emergency room if you experience hives, swelling of your face, mouth, or tongue, trouble breathing, dizziness, or changes in your blood cell counts.

Can I take Pletoz with vitamins or supplements?

Pletoz can generally be taken with vitamins or supplements, but some may interact with its effectiveness or increase side effects. For example, grapefruit or supplements affecting blood thinning (like vitamin E, ginkgo biloba, or omega-3 fatty acids) could increase the risk of bleeding. Always consult your healthcare provider before adding any new supplements to your regimen.

Can I take Pletoz with other prescription drugs?

Pletoz may interact with blood thinners, antiplatelets, antibiotics, and drugs affecting CYP3A4 or CYP2C19 enzymes (e.g., omeprazole, diltiazem). Inform your doctor about all medications to ensure safe use.

Can Pletoz be taken safely while pregnant?

It is not known if Pletoz tablets can harm an unborn baby or if it passes into breast milk. Talk to your doctor about whether to use Pletoz tablets or breastfeed. You should not do both.

Can Pletoz be taken safely while breastfeeding?

Pletoz, a medication used to treat certain blood flow problems, can pass into breast milk and harm a nursing baby. Therefore, you should either stop nursing or stop taking Pletoz. Discuss with your doctor to determine the best option for your specific situation.

Is Pletoz safe for the elderly?

In general, people of all ages can use this medication safely and effectively. However, some older people may be more sensitive to it, so it's important to monitor them closely. The way the body absorbs, distributes, breaks down, and gets rid of the medication doesn't change with age.

How should I store Pletoz?

Keep Pletoz tablets in a cool, dry place at room temperature. Make sure it's between 68°F to 77°F (20°C to 25°C). Keep all medicines away from children.

Does Pletoz make people tired or drowsy?

Pletoz can cause dizziness (10%) and fatigue (<2%). If these occur, patients should avoid activities requiring alertness and consult their doctor for advice on managing these side effects​.

Does Pletoz cause stomach upset?

Pletoz frequently causes gastrointestinal side effects like diarrhea (19%), abnormal stools (15%), and dyspepsia (6%). These occur in more than 1 in 10 patients. If symptoms persist, patients should inform their doctor to consider dose adjustment or alternative treatment​

Does Pletoz affect sleep?

Insomnia has been reported but occurs in less than 2% of patients. Patients experiencing significant sleep disturbances should consult their healthcare provider for evaluation and possible treatment modifications

Does Pletoz make it hard to think or concentrate?

Dizziness (10%) and headaches (34%) may interfere with cognitive functions. Patients experiencing difficulty concentrating should avoid mentally demanding tasks and discuss these effects with their doctor​.

Does Pletoz affect mood?

While no direct mood effects are noted, dizziness and fatigue could indirectly affect emotional well-being. Patients with mood concerns should seek medical advice.

Does Pletoz interfere with sexual function?

Sexual dysfunction is not a commonly reported side effect of Pletoz. Patients should discuss any related issues with their doctor for proper evaluation

Does Pletoz affect appetite?

Anorexia (loss of appetite) has been reported in less than 2% of cases. Patients experiencing significant appetite changes should notify their doctor​.

Does Pletoz cause weight gain?

Weight changes are not commonly associated with Pletoz. Patients should monitor their weight and consult their doctor if significant changes occur​.

Does Pletoz cause headaches?

Pletoz is a medication that can cause headaches. It's more likely to happen in people taking 100 mg of the medication twice a day. About 3 out of 10 people experience headaches with this dosage. If you get a headache while taking Pletoz, talk to your doctor.

Does Pletoz limit driving?

Dizziness (10%) and fatigue may impair driving. Patients are advised to avoid driving until they are familiar with how the medicine affects them and consult their doctor if symptoms interfere with their daily activities​.

What are Pletoz possible harms and risks?

Pletoz is a medication used to improve blood flow to the legs and arms. It can cause side effects such as headache, loose stools, and diarrhea. In some cases, side effects can be severe enough to stop taking the medication. Pletoz prevents blood cells from sticking together, which helps to improve blood flow.