orinate
Orinate 60mg Injection contains Artesunate, which is a medication primarily utilized for the treatment of malaria, particularly in severe cases. Belonging to the artemisinin class of medications holds a place on the World Health Organization's List of Essential Medicines.
It functions as a prodrug, rapidly converting to its active form, dihydroartemisinin (DHA). This transformation generates reactive oxygen species, inducing oxidative stress and causing damage to malarial proteins. Additionally, it inhibits the essential Plasmodium falciparum exported protein 1 (EXP1), reducing parasite glutathione levels.
While generally well-tolerated, common side effects may include a slow heartbeat, allergic reactions, dizziness, and low white blood cell levels In severe cases, kidney failure requiring dialysis, hemoglobinuria (presence of hemoglobin in urine), and jaundice have been reported.
It is considered safe during pregnancy, particularly in the second and third trimesters, although caution is advised in the first trimester. It is generally safe for use in children, with adjustments in dosing for those under 20 kg. Notably, it should be avoided in newborns when combined with sulfadoxine/pyrimethamine due to potential effects on bilirubin.
In the event of a missed dose, it is crucial to consult with a healthcare professional for guidance on the appropriate course of action. The timing and severity of the missed dose will be considered to determine the most suitable response.
Available in 2 variations
Orinate 60mg Injection
Orinate 60mg Injection
vial of 1 Powder for Injection
Orinate 50mg Tablet
Orinate 50mg Tablet
strip of 4 tablets
Related Faqs
Is Arh Plus banned in India?
The availability of this particular medication is restricted to India and can only be obtained with a legitimate prescription from a qualified medical professional It is not accessible overthecounter or through other means without proper authorization This precaution ensures that the medication is used safely and effectively as prescribed by a healthcare provider who has evaluated the individuals specific medical condition and needs Engaging in selfmedication or obtaining the medication without the necessary expertise and supervision can lead to potential risks and adverse effects Therefore it is essential to adhere to the regulations and consult a healthcare practitioner in India to obtain a prescription for this medication By doing so individuals can ensure their health and wellbeing are prioritized while utilizing the medication appropriately for their medical requirements
Is Malart banned in India?
In India the accessibility of certain medications is strictly controlled and monitored One such medicine requiring a doctors prescription is available exclusively through this regulated process This practice aims to ensure the safety and wellbeing of individuals by preventing the misuse or improper administration of potentially harmful drugs By implementing these restrictions the government and medical authorities aim to minimize the risks associated with selfmedication and encourage individuals to consult a healthcare professional for proper diagnosis and prescription This system plays a crucial role in safeguarding public health and upholding ethical standards in the pharmaceutical industry Therefore if one wishes to obtain this particular medicine in India it is essential to consult a qualified doctor who can assess the individuals condition and prescribe the appropriate treatment By following this established protocol individuals can receive the necessary medication while also prioritizing their health and wellbeing
How does Falno work?
The mechanism of action involves the generation of free radicals which effectively eradicates the malarial parasite known as Plasmodium This process plays a crucial role in combating the harmful effects of malaria By producing these highly reactive molecules the medication targets the parasite and disrupts its vital functions leading to its eventual demise These free radicals possess a remarkable ability to destroy the intricate structure of the Plasmodium parasite effectively neutralizing its growth and reproduction This innovative mode of action ensures the elimination of the parasite thereby alleviating the symptoms of malaria and preventing its further progression The selective action of this medication on the malarial parasite guarantees a targeted approach maximizing the efficacy of treatment and minimizing potential side effects Ultimately through the generation of free radicals this drug demonstrates its effectiveness in eradicating the Plasmodium parasite offering hope to those afflicted with malaria and contributing to the global efforts in combating this widespread and devastating disease
Where does Orinate come from?
Artemisinin is a naturally occurring compound derived from the Artemisinin tree also known as sweet wormwood or Qing Hao This plant scientifically called Artemisia annua has been used for centuries in traditional Chinese medicine to treat various ailments However it wasnt until its potent antimalarial properties were discovered that Artemisinin gained significant attention in the medical community Artemisinins discovery revolutionized the treatment of malaria a mosquitoborne infectious disease that claims hundreds of thousands of lives annually The discovery was made in the 1970s by Chinese scientist Tu Youyou who was awarded the Nobel Prize in Physiology or Medicine for her groundbreaking work Tus research demonstrated that Artemisinin effectively combats the malaria parasite Plasmodium and its derivatives are now considered vital components of the most effective antimalarial treatments available Since its discovery Artemisinin has not only saved countless lives but has also played a crucial role in reducing global malariarelated mortality rates This natural compound acts by producing free radicals in the presence of iron which selectively destroys the malaria parasites while leaving the human cells unharmed This targeted approach ensures minimal side effects and promotes a faster recovery The importance of Artemisinin extends beyond malaria treatment Ongoing research aims to explore its potential applications in treating other diseases such as cancer Preliminary studies have shown promising results indicating that Artemisinin could inhibit the growth of cancer cells making it a subject of great interest for further investigation In conclusion Artemisinin derived from the Artemisinin tree holds immense value in the medical field Its significant contribution to malaria treatment and potential in combating other diseases make it a remarkable compound deserving of continuous study and exploration
How does Orinate work?
The mechanism of action of this substance is to generate and release reactive molecules known as free radicals These free radicals play a critical role in the eradication of the malarial parasite also referred to as Plasmodium The free radicals are highly reactive and have the ability to damage essential cellular components within the parasite leading to its ultimate demise By targeting the parasite specifically and sparing healthy host cells this substance effectively eliminates the malarial infection while minimizing potential harm to the individual undergoing treatment The production of free radicals by this substance serves as a powerful weapon against the Plasmodium parasite Once released these highly reactive molecules initiate a cascade of damaging events within the parasites cellular structure The free radicals directly attack key components vital for the parasites survival and replication including DNA proteins and membranes This onslaught of oxidative damage overwhelms the parasites defense mechanisms causing severe disruption to its normal physiological processes Additionally the generation of free radicals by this substance helps to overcome the parasites resistance mechanisms Due to their high reactivity free radicals are less prone to developing resistance compared to traditional antimalarial drugs This unique mode of action makes the substance an effective option for treating malarial infections particularly in cases where the parasite has developed resistance to other medications In conclusion through the production of free radicals this substance exhibits a potent and targeted action against the malarial parasite By delivering a specific and damaging blow to its cellular components it effectively eliminates the infection while minimizing harm to the host Its ability to overcome resistance mechanisms further solidifies its role as an important weapon in the fight against malaria
Is Orinate banned in India?
No the medication is available in India but can only be obtained with a valid doctors prescription In order to ensure the safe and responsible use of certain medications it is mandatory for individuals to consult with a qualified medical professional before being granted access to them This system of regulation helps safeguard public health and prevents the misuse or abuse of pharmaceutical drugs By requiring a prescription doctors can evaluate the patients medical history diagnose the condition accurately and prescribe the appropriate dosage and duration of treatment This ensures that patients receive the medication they need while minimizing the risk of adverse effects or complications Additionally the prescriptiononly requirement helps prevent the sale and distribution of counterfeit or substandard medications protecting individuals from potential harm It is therefore essential to consult with a healthcare professional in India to obtain the necessary prescription and access the medication safely and legally
Disclaimer : This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment . Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.
orinate
Prescription Required
Manufacturer :
Forgo Pharmaceuticals Pvt LtdComposition :
artesunateMRP :
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