Trexasure M 500mg/250mg Tablet TRANEXAMIC ACID + MEFENAMIC ACID
Trexasure M 500mg/250mg Tablet is combination of medicine is used to relieve dysmenorrhea, commonly known as period pain, and menorrhagia, which refers to heavy menstrual bleeding.
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Are the medicines in combination of Mefenamic acid and Tranexamic Acid safe to take together?
Mefenamic acid and tranexamic acid can both affect blood clotting, so using them together may increase the risk of bleeding or thrombotic events. Monitoring for signs of bleeding, such as unusual bruising or blood in stools, and signs of thrombosis, like swelling or pain in the limbs, is important. Regular follow-up with a healthcare provider is recommended to assess for any adverse effects or interactions, especially if other medications affecting clotting are also being used.
Are there harms and risks from taking combination of Mefenamic acid and Tranexamic Acid?
Common side effects of mefenamic acid include diarrhea, constipation, headache, and dizziness, while tranexamic acid may cause headache, sinus pain, and back pain. Significant adverse effects for mefenamic acid can include gastrointestinal bleeding and cardiovascular events, whereas tranexamic acid may lead to thromboembolic events. Both medications share common side effects like headache and should be used with caution in individuals with a history of cardiovascular or bleeding disorders.
Can I take combination of Mefenamic acid and Tranexamic Acid if I am pregnant?
Mefenamic acid is not recommended during pregnancy, especially in the third trimester, due to the risk of affecting fetal cardiovascular function. Tranexamic acid should also be used with caution during pregnancy, as it crosses the placenta, although no adverse developmental outcomes have been identified in animal studies. Both medications should only be used during pregnancy if the potential benefits outweigh the risks, and under the guidance of a healthcare provider.
Can I take combination of Mefenamic acid and Tranexamic Acid while breastfeeding?
Mefenamic acid is present in breast milk in small amounts, and while it is generally considered safe, it should be used with caution during breastfeeding. Tranexamic acid is also excreted in breast milk, but the concentration is low, and it is unlikely to affect the nursing infant. Both medications should be used under medical supervision during lactation, and any concerns should be discussed with a healthcare provider to ensure the safety of the infant.
Can I take combination of Mefenamic acid and Tranexamic Acid with other prescription drugs?
Mefenamic acid can interact with anticoagulants, other NSAIDs, and SSRIs, increasing the risk of bleeding. Tranexamic acid should not be used with hormonal contraceptives due to an increased risk of thrombosis. Both medications require careful monitoring when used with other drugs that affect blood clotting or cardiovascular function. Patients should always inform their healthcare provider of all medications they are taking to avoid potential interactions.
For how long is combination of Mefenamic acid and Tranexamic Acid taken?
Mefenamic acid is typically used for up to one week to manage pain, while tranexamic acid is used for up to 5 days during menstruation to control heavy bleeding. Both medications are intended for short-term use and should be taken as directed by a healthcare provider. The duration of use is limited to minimize potential side effects and ensure effectiveness for their specific indications.
How does combination of Mefenamic acid and Tranexamic Acid work?
Mefenamic acid works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins, substances that mediate inflammation and pain. Tranexamic acid works by inhibiting the breakdown of fibrin, a protein that helps in blood clotting, thereby reducing excessive bleeding. Both medications act to alleviate symptoms associated with menstruation, but they target different pathways: mefenamic acid reduces pain and inflammation, while tranexamic acid reduces bleeding.
How does one take combination of Mefenamic acid and Tranexamic Acid?
Mefenamic acid should be taken with food to minimize stomach upset, while tranexamic acid can be taken with or without food. There are no specific food restrictions for either medication, but it is important to follow the prescribed dosing schedule. Both medications should be taken as directed by a healthcare provider, and patients should report any unusual symptoms or side effects to their doctor.
How do I know if combination of Mefenamic acid and Tranexamic Acid is working?
The benefit of mefenamic acid is assessed by the reduction in pain and inflammation, often measured by patient-reported outcomes such as decreased pain levels and improved mobility. For tranexamic acid, the benefit is measured by the reduction in menstrual blood loss, which can be quantified by the number of sanitary products used or through clinical assessments. Both medications aim to improve quality of life by addressing specific symptoms: pain for mefenamic acid and heavy bleeding for tranexamic acid.
How do I store combination of Mefenamic acid and Tranexamic Acid?
Neither mefenamic acid nor tranexamic acid requires refrigeration. Both medications should be stored at room temperature, away from excess heat and moisture, and kept in their original containers with the lids tightly closed. It is important to keep these medications out of reach of children to prevent accidental ingestion.
How effective is combination of Mefenamic acid and Tranexamic Acid?
Clinical trials have demonstrated the effectiveness of mefenamic acid in reducing pain and inflammation associated with conditions like dysmenorrhea. Similarly, studies have shown that tranexamic acid significantly reduces menstrual blood loss in women with heavy menstrual bleeding. Both medications have been proven effective in their respective roles through controlled studies, with mefenamic acid providing pain relief and tranexamic acid reducing bleeding. Their effectiveness is supported by patient-reported outcomes and clinical measurements.
How long does it take for combination of Mefenamic acid and Tranexamic Acid to work?
Mefenamic acid, an NSAID, typically begins to relieve pain within 30 minutes to an hour after ingestion, as it works by reducing the production of substances in the body that cause inflammation and pain. Tranexamic acid, on the other hand, is used to reduce heavy menstrual bleeding and may take a few hours to start showing effects as it works by promoting blood clotting. Both medications are taken orally and start working relatively quickly, but their effects are specific to their individual purposes: pain relief for mefenamic acid and reduction of bleeding for tranexamic acid.
What disease or symptom is combination of Mefenamic acid and Tranexamic Acid used for?
Mefenamic acid is indicated for the relief of mild to moderate pain, including menstrual pain, while tranexamic acid is used to treat heavy menstrual bleeding. Both medications are commonly used in the context of menstrual disorders, but they address different symptoms: mefenamic acid targets pain and inflammation, whereas tranexamic acid focuses on reducing excessive blood loss. They are both part of the management of menstrual-related conditions.
What is combination of Mefenamic acid and Tranexamic Acid?
Mefenamic acid is commonly used to relieve mild to moderate pain, including menstrual pain, by inhibiting the production of substances that cause inflammation and pain. Tranexamic acid is used to treat heavy menstrual bleeding by promoting blood clotting and reducing blood loss. Both medications are taken orally and are used to manage symptoms related to menstruation, but they work through different mechanisms: mefenamic acid as an anti-inflammatory and tranexamic acid as an antifibrinolytic.
What is the usual dose of combination of Mefenamic acid and Tranexamic Acid?
For mefenamic acid, the usual adult dose for pain relief is 500 mg initially, followed by 250 mg every 6 hours as needed, not exceeding one week of use. For tranexamic acid, the typical dose is 1300 mg taken three times a day (totaling 3900 mg per day) for up to 5 days during menstruation. Both medications are taken orally and should be used as directed by a healthcare provider. Mefenamic acid is primarily for pain relief, while tranexamic acid is used to manage heavy menstrual bleeding.
Who should avoid taking combination of Mefenamic acid and Tranexamic Acid?
Mefenamic acid is contraindicated in individuals with a history of gastrointestinal bleeding or cardiovascular disease, while tranexamic acid should not be used in those with active thromboembolic disease or a history of thrombosis. Both medications should be used with caution in patients with renal impairment. It is crucial to follow medical advice and report any unusual symptoms, such as chest pain or severe headache, to a healthcare provider immediately.
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