duragest (PROGESTERONE)

What is Duragest?

Duragest is commonly used to treat hormonal imbalances, support pregnancy in women with luteal phase defects, and manage menstrual disorders. It works by mimicking the natural hormone Duragest, which regulates the menstrual cycle, supports pregnancy by preparing the uterus for implantation, and prevents the lining from shedding prematurely. It is also used in hormone replacement therapy (HRT).

What is the usual dose of Duragest?

This medicine's dosage depends on why you're taking it and your age. For adult women with certain conditions, the amount is different. For preventing a specific uterine problem after menopause, the dose is 200mg nightly for 12 days out of every 28. For another condition (lack of periods), the dose is higher (400mg nightly) for 10 days. This medicine isn't meant for children.

How do I take Duragest?

Duragest can be taken with or without food. However, taking it with food may help reduce any stomach upset. There are no specific food restrictions when using Duragest, but it is recommended to follow your doctor’s advice regarding dosage timing and any lifestyle adjustments.

For how long do I take Duragest?

• Endometrial Hyperplasia Prevention: Use in 28-day cycles as prescribed by your healthcare provider.
• Secondary Amenorrhea: For 10 days per treatment cycle, or as directed by your healthcare provider​

What is Duragest used for?

Duragest is used for hormone replacement therapy (HRT) in menopause, pregnancy support, menstrual disorders, endometrial protection, and endometriosis. It also helps in preventing preterm birth in some cases.

How long does it take for Duragest to start working?

The effects of Duragest can be felt within a few days to weeks, depending on the condition being treated. For menstrual disorders, it may take a few days to regulate the cycle. For pregnancy support, it helps maintain the uterine lining, and its effects are monitored over weeks. The full benefits, especially in HRT, may take several weeks to become evident.

Is Duragest effective?

Clinical studies support the effectiveness of Duragest in various conditions. For menstrual disorders, it has been shown to regulate cycles and reduce abnormal bleeding. In pregnancy support, it helps maintain uterine lining, reducing the risk of miscarriage. Evidence also confirms its role in HRT, improving menopause symptoms and protecting the endometrium. These benefits are well-documented in research and clinical practice.

How does one know if Duragest is working?

The benefits of Duragest are evaluated by monitoring improvements in symptoms such as menstrual regularity, pregnancy maintenance, and menopause symptom relief. For pregnancy support, doctors check hormone levels and ultrasound scans. In HRT, doctors assess symptom relief and ensure the uterine lining remains protected. Evaluation involves blood tests, patient symptom tracking, and medical exams.

How does Duragest work?

Duragest works by mimicking the natural hormone Duragest in the body. It plays a key role in regulating the menstrual cycle, preparing the uterus for implantation of a fertilized egg, and maintaining pregnancy by preventing uterine contractions. In hormone replacement therapy (HRT), it balances the effects of estrogen and protects the uterus from potential risks like endometrial cancer.

Who should avoid taking Duragest?

Warnings for Duragest include caution in individuals with a history of blood clots, liver disease, or breast cancer. It should be used cautiously in people with depression or heart disease.

Contraindications include active liver disease, unexplained vaginal bleeding, and allergy to Duragest. It should also be avoided in pregnancy unless prescribed for support. Always consult a doctor before use.

Can I take Duragest with vitamins or supplements?

Duragest has minimal interactions with vitamins or supplements. However, taking vitamin E in high doses may increase the risk of blood clots when combined with Duragest, as both can have anticoagulant effects. It’s advisable to monitor the use of herbal supplements like St. John's Wort, which may decrease Duragest's effectiveness. Always consult a healthcare provider before combining supplements with Duragest.

Can I take Duragest with other prescription drugs?

1. Anticoagulants (e.g., warfarin): Duragest may reduce the effectiveness of blood thinners, increasing the risk of clotting.
2. CYP450 enzyme inhibitors (e.g., ketoconazole, ritonavir): These can increase Duragest levels, potentially enhancing side effects.
3. Anticonvulsants (e.g., phenytoin, carbamazepine): These may reduce Duragest levels, lowering its effectiveness.

Can Duragest be taken safely while pregnant?

Duragest is commonly used during pregnancy to support the uterine lining and prevent miscarriage, particularly in women with a history of pregnancy loss or luteal phase defects. It is generally considered safe when used as prescribed during pregnancy. However, its use should be monitored to avoid potential side effects. Consult a healthcare provider for individualized guidance.

Can Duragest be taken safely while breastfeeding?

Duragest is excreted in breast milk in small amounts, but it is generally considered safe for use during lactation. There is no significant evidence suggesting that it negatively affects the infant. However, if high doses or long-term use is required, it’s important to consult a healthcare provider to ensure it’s the best choice while breastfeeding.

Is Duragest safe for the elderly?

For women over 65, using Duragest alone or with estrogen hasn't been proven safe or helpful. In fact, combining estrogen and Duragest can increase the chances of stroke, breast cancer, and possibly dementia. Doctors don't recommend this combination to prevent heart problems or dementia.

How should I store Duragest?

Duragest needs to be kept at a temperature between 68° to 77°F (20° to 25°C). This is the recommended storage temperature to maintain the effectiveness of the medication.

Does Duragest make people tired or drowsy?

Yes, drowsiness is common. Take it at bedtime and avoid driving or operating machinery if affected​.

Does Duragest cause stomach upset?

Yes, abdominal bloating (12%) and nausea (8%) are reported. Consult a doctor if symptoms are severe​.

Does Duragest affect sleep?

Duragest pills can make you sleepy or dizzy, especially when you first start taking them. Some women get very sleepy. If this affects your sleep, talk to your doctor right away.

Does Duragest make it hard to think or concentrate?

Dizziness and confusion are possible, particularly during initial therapy. Avoid tasks requiring focus if affected​.

Does Duragest affect mood?

Mood changes, including depression (19%), have been reported. Notify your doctor if symptoms worsen​.

Does Duragest interfere with sexual function?

Breast tenderness and vaginal discharge may occur, potentially affecting sexual comfort, though libido effects are not explicitly note.

Does Duragest affect appetite?

No significant effects on appetite were reported​.

Does Duragest cause weight gain?

Some people may gain or lose weight while taking this medicine. How often this happens isn't known. If your weight changes, talk to your doctor.

Does Duragest cause headaches?

Duragest pills can sometimes cause headaches. If you get a headache while taking them, talk to your doctor. A really bad headache needs immediate medical help.

Does Duragest limit driving?

This medicine might make you feel dizzy or sleepy. If this happens, don't drive or use any tools or machines. If you get too dizzy to drive safely, pull over, stop driving, and call your doctor right away.

Is it safe to drink alcohol while taking Duragest?

Alcohol may worsen drowsiness or dizziness. Avoid combining them​.

Is it safe to drink coffee or tea while taking Duragest?

No specific interaction with caffeine is noted, but excessive use might exacerbate restlessness or sleep issues​.

Is it safe to exercise while taking Duragest?

Exercise is generally safe. Avoid strenuous activities if dizziness or fatigue occurs​.

What are Duragest possible harms and risks?

Common side effects of Duragest include headache, breast tenderness, mood changes, fatigue, and dizziness.

Significant adverse effects may include severe allergic reactions, blood clots, liver issues, and abnormal vaginal bleeding. In rare cases, it can cause depression or pregnancy-related complications. Contact a doctor if any severe side effects occur.