Arthlast Tablet (APREMILAST)

What is Arthlast tablet?

Arthlast tablet is a pill that helps treat a condition called psoriatic arthritis, which causes painful and swollen joints. It works by increasing the amount of a chemical in the body called cAMP. This chemical helps reduce inflammation and pain in the joints.

What is the usual dose of Arthlast tablet?

For adults with psoriatic arthritis, plaque psoriasis, or Behçet's Disease, the recommended maintenance dose is 30 mg twice daily after a 5-day titration period. For children aged 6 years and older with moderate to severe plaque psoriasis, the dose is based on weight: 30 mg twice daily for those weighing at least 50 kg, and 20 mg twice daily for those weighing 20 kg to less than 50 kg.

How do I take Arthlast tablet?

You can take Arthlast tablet with or without food. Swallow the tablets whole. Do not crush, split, or chew them.

For how long do I take Arthlast tablet?

Arthlast tablet is used up to 5 years in patients with psoriasis, psoriatic arthritis, or Behçet's syndrome for long term treatment.

What disease or symptom is Arthlast tablet used for?

Arthlast tablet is a medication used to treat three conditions:

1. Psoriatic Arthritis: A type of arthritis that causes pain, swelling, and stiffness in the joints, especially those of the fingers, toes, and spine.

2. Plaque Psoriasis: A skin condition that causes red, raised, scaly patches on the skin, often on the elbows, knees, and scalp.

3. Oral Ulcers Associated with Behçet's Disease: Painful sores in the mouth that occur as a symptom of Behçet's disease, a rare autoimmune disorder.

How long does it take for Arthlast tablet to start working?

Arthlast tablet typically starts showing noticeable effects within 2 to 4 weeks, but for some conditions, like psoriatic arthritis or plaque psoriasis, it may take up to 16 weeks to achieve full benefits. Regular use as prescribed is essential to see optimal results. Always consult your doctor if improvement seems delayed.

Is Arthlast tablet effective?

Yes, Arthlast tablet is effective for many people in managing conditions like psoriasis and psoriatic arthritis. It helps reduce inflammation, improve joint symptoms, and decrease the severity of skin plaques. While results vary, many patients notice improvement within 2–16 weeks of consistent use. Always follow your doctor’s guidance for the best outcomes.

How do I know if Arthlast tablet is working?

You can tell Arthlast tablet is working if you notice:

1. Reduced skin lesions – Decreased size or appearance of psoriasis patches.
2. Less joint pain – Reduced inflammation, pain, and swelling in psoriatic arthritis.
3. Improved mobility – Easier movement and less stiffness.

It may take 2 to 16 weeks to see noticeable improvements. Consult your doctor if symptoms don’t improve.

How does Arthlast tablet work?

Arthlast tablet works by inhibiting an enzyme called phosphodiesterase 4 (PDE4), which reduces the production of inflammatory chemicals in the body. This helps lower inflammation, relieving symptoms like joint pain, swelling, and skin lesions in conditions such as psoriasis and psoriatic arthritis.

Who should avoid taking Arthlast tablet?

People with an allergy to Arthlast tablet or other ingredients in the medicine should not take the medicine. Some people may have allergic reactions, including hives and swelling of the face, lips, tongue, or throat.

People 65 and older and those taking certain medications that can cause dehydration or low blood pressure may be at higher risk of problems from severe diarrhea, nausea, or vomiting.

The most common side effects of Arthlast tablet are diarrhea, nausea, headache, and vomiting.

Can I take Arthlast tablet with other prescription drugs?

If you take Arthlast tablet with strong CYP450 inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin), the amount of Arthlast tablet in your body will decrease. This can make Arthlast tablet less effective. Therefore, it's not recommended to take Arthlast tablet with these medications.

Can Arthlast tablet be taken safely while pregnant?

Arthlast tablet is not recommended during pregnancy unless necessary, as its safety is not well established. If you're pregnant or planning to get pregnant, consult your doctor to weigh the risks and benefits.

Can Arthlast tablet be taken safely while breastfeeding?

Arthlast tablet should be used with caution while breastfeeding, as it’s unclear if it passes into breast milk. It's best to consult your doctor before taking Arthlast tablet while breastfeeding to weigh potential risks and benefits.

Is Arthlast tablet safe for the elderly?

Arthlast tablet can generally be used by elderly patients, but they may be more susceptible to side effects, such as gastrointestinal issues or infections. Dose adjustments are typically not necessary, but careful monitoring is recommended. Always consult a doctor to assess the individual risks and ensure safe use.

How should I store Arthlast tablet?

Arthlast tablet should be stored at room temperature, away from moisture and heat, typically between 68°F to 77°F (20°C to 25°C). Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom or near sources of heat or humidity.

Does Arthlast tablet make people tired or drowsy?

Arthlast tablet does not commonly cause tiredness or drowsiness. However, some people may experience headaches or mood changes, which could indirectly affect energy levels. If you feel unusually tired or drowsy while taking Arthlast tablet, consult your doctor to assess the cause and find possible solutions.

Does Arthlast tablet cause stomach upset?

Yes, Arthlast tablet can cause stomach upset, including side effects like nausea, diarrhea, and stomach pain. These are common, especially when starting the medication. If symptoms persist or worsen, consult your doctor for advice on managing these effects.

Does Arthlast tablet affect sleep?

Arthlast tablet is not commonly associated with sleep disturbances. However, some people may experience side effects like headache or mood changes, which could indirectly affect sleep. If you have trouble sleeping while taking Arthlast tablet, consult your doctor to assess the situation.

Does Arthlast tablet make it hard to think or concentrate?

Arthlast tablet can cause side effects like headache and mood changes, which may affect focus or concentration in some people. However, difficulty thinking or concentrating is not a common side effect. If you experience significant cognitive issues, contact your doctor for guidance.

Does Arthlast tablet affect mood?

Yes, Arthlast tablet can affect mood in some people, causing symptoms like depression, anxiety, or mood swings. If you experience significant mood changes, it’s important to talk to your doctor to evaluate the situation and adjust your treatment if necessary.

Does Arthlast tablet interfere with sexual function?

Arthlast tablet is not commonly associated with sexual function issues. However, some people may experience side effects like mood changes or fatigue, which could indirectly affect libido or sexual performance. If you notice any changes in sexual function while taking Arthlast tablet, consult your doctor for guidance.

Does Arthlast tablet affect appetite?

Arthlast tablet may cause weight loss in some people, which could affect appetite. This side effect is not very common but may occur. If you notice significant changes in appetite or weight, it’s important to consult your doctor to ensure there are no underlying issues.

Does Arthlast tablet cause weight gain?

Arthlast tablet is more commonly associated with weight loss rather than weight gain. Some individuals may experience a decrease in appetite or gastrointestinal issues, which can lead to weight loss. However, if you notice unexpected weight gain while taking Arthlast tablet, it’s important to consult your doctor.

Does Arthlast tablet cause headaches?

Yes, Arthlast tablet can cause headaches as a common side effect, especially when starting the medication. If headaches persist or become severe, consult your doctor to discuss possible adjustments or treatments to manage this side effect.

Does Arthlast tablet limit driving?

Arthlast tablet does not typically cause drowsiness or impair coordination, so it generally does not limit driving. However, if you experience side effects like headaches, dizziness, or mood changes, it may be best to avoid driving until you know how the medication affects you. Always consult your doctor if you're unsure.

Is it safe to drink alcohol while taking Arthlast tablet?

Most people tolerate Arthlast tablet well, and occasional alcoholic drinks should not affect the way this medicine works. There are no well-established interactions between Arthlast tablet and alcohol that would interfere with the medication's effectiveness or cause harm. However, it's always wise to consume alcohol in moderation and be mindful of how your body reacts. If you notice any unusual symptoms, consult your healthcare provider for guidance.

Is it safe to drink coffee or tea while taking Arthlast tablet?

Most people tolerate Arthlast tablet well, and it should not limit your ability to drink caffeinated beverages such as coffee or tea. There are no known interactions between Arthlast tablet and caffeine that would interfere with the medication's effectiveness or cause harm. However, it's always a good idea to consume caffeine in moderation and monitor how your body responds. If you experience any unusual symptoms, consult your healthcare provider for advice.

Is it safe to exercise while taking Arthlast tablet?

Most people tolerate Arthlast tablet well, and it should not limit your ability to exercise. There is no information suggesting that this medicine causes symptoms that would limit exercise capacity, physical strength, or endurance. However, if you experience any unusual symptoms during physical activity, such as dizziness or fatigue, take precautions and consult your healthcare provider for advice. It's always a good idea to listen to your body and adjust your exercise routine as needed.

What are the most common side effects of Arthlast tablet?

Side effects are unwanted effects that can occur with medication use. Common side effects of Arthlast tablet include diarrhea, nausea, headache, upper respiratory tract infection, and weight loss. These effects are generally mild and may go away over time. It's important to remember that new symptoms can occur when starting any new medicine, and they may not always be related to the medication. Always speak to your healthcare provider before stopping any medicine, as they can help determine the cause of symptoms and provide guidance.

Does Arthlast tablet have adverse effects?

Adverse effects are unwanted or harmful effects that can occur with medication use. For Arthlast tablet, common adverse effects include diarrhea, nausea, headache, and weight loss. These are generally mild but can be bothersome. Rare but serious adverse effects may include severe allergic reactions or mood changes, which require immediate medical attention. It's important to report any new or worsening symptoms to your healthcare provider and consult them before stopping the medication.

Is Arthlast tablet addictive?

Arthlast tablet is not known to be addictive or habit-forming. There is no evidence to suggest that it causes physical or psychological dependence. Therefore, you don't need to worry about addiction when taking this medication. However, it's always important to follow your healthcare provider's instructions and report any unusual symptoms or concerns you may have while using Arthlast tablet.

Does Arthlast tablet have any safety warnings?

Arthlast tablet comes with safety warnings, including the risk of depression and suicidal thoughts. It's important to monitor mood changes and report any feelings of depression or suicidal thoughts to your doctor immediately. Weight loss is another concern, so regular weight checks are advised. Allergic reactions, though rare, can occur, so watch for symptoms like rash, itching, or swelling. Always inform your healthcare provider about any new symptoms or concerns while taking Arthlast tablet.

Is it safe to stop Arthlast tablet?

Arthlast tablet is typically used for long-term management of chronic conditions like psoriasis or psoriatic arthritis. Stopping it abruptly may lead to a return of symptoms or worsening of the condition. There are no known withdrawal symptoms, but it's crucial to consult your doctor before stopping the medication. They can guide you on how to safely discontinue use if necessary, ensuring that your condition remains managed effectively.

How do I dispose of Arthlast tablet?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.

What are Arthlast tablet possible harms and risks?

Arthlast tablet can cause side effects like diarrhea, headache, nausea, infections, mood changes, and weight loss. Consult your doctor if you experience any concerns.